Kiss A, Telek B, Oláh E, Pecze K, Iványi J, Rak K
Acta Med Hung. 1986;43(3):291-300.
138 CGL-patients were treated in 1974-1984. The female-male ratio was 1.26. In the majority (82.3%) of the 68 patients having died at the blastic phase, all three phases of the disease could be followed. The chronic phase lasted for 31 months. The accelerated disease was detectable in 56 patients, with a mean duration of 5.3 months. The blastic phase, lasting for 4.1 months, was morphologically heterogeneous. Using adequate methods, several groups could be distinguished, i.e. myeloid in 38.3, promyelocytic in 2.9, myelomonocytic in 19.1, megakaryoblastic in 14.7, lymphoblastic in 13.2 and mixed blastic in 11.8%. 23 patients died prior to the development of the blastic phase (9 in the chronic phase, 12 in the accelerated phase and two with chronic neutrophilic leukaemia). The mean survival was in accordance with that in the literature, i.e. 40.6 months. The shortest survival was shown by the lymphoblastic group with the difference manifesting already in the chronic phase. Females survived 13-14 months longer than did males.
1974年至1984年期间，对138例慢性粒细胞白血病（CGL）患者进行了治疗。男女比例为1.26。在68例死于急变期的患者中，大多数（82.3%）患者的疾病三个阶段均可追溯。慢性期持续31个月。56例患者可检测到加速期，平均持续时间为5.3个月。急变期持续4.1个月，形态学上具有异质性。采用适当方法可区分出几个组，即髓细胞性占38.3%、早幼粒细胞性占2.9%、粒单核细胞性占19.1%、巨核细胞性占14.7%、淋巴细胞性占13.2%、混合急变期占11.8%。23例患者在急变期出现之前死亡（9例死于慢性期，12例死于加速期，2例患有慢性中性粒细胞白血病）。平均生存期与文献报道一致，即40.6个月。淋巴细胞性组生存期最短，差异在慢性期就已显现。女性比男性多存活13 - 14个月。
