伴刀豆球蛋白A对肿瘤细胞结合67镓的影响。
Effects of concanavalin A on 67Ga binding by tumor cells.
作者信息
Anghileri L J, Crone-Escanye M C, Robert J
出版信息
Nuklearmedizin. 1987 Apr;26(2):105-7.
The in vitro uptakes of 67Ga-citrate and 45Ca-chloride in the presence of concanavalin A have shown that at low concentrations (10-50 micrograms/ml) 67Ga presents a significant increase not observed for 45Ca. At higher concentrations there is a sharp augmentation of both 67Ga and 45Ca incorporations. The augmentation of Trypan blue inclusion is a concomitant phenomenon at any concanavalin A concentration that indicates tumor cell plasma membrane changes in direct relationship with 67Ga uptake increase.
在伴刀豆球蛋白A存在的情况下，对67镓-柠檬酸盐和45钙-氯化物的体外摄取研究表明，在低浓度（10 - 50微克/毫升）时，67镓的摄取量显著增加，而45钙则未观察到这种现象。在较高浓度时，67镓和45钙的摄取量都急剧增加。在任何伴刀豆球蛋白A浓度下，锥虫蓝摄取量的增加都是一种伴随现象，这表明肿瘤细胞质膜的变化与67镓摄取量的增加直接相关。
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