盐酸普萘洛尔增强小鼠肉瘤中肿瘤灌注及镓 - 67摄取

Propranolol hydrochloride enhancement of tumor perfusion and uptake of gallium-67 in a mouse sarcoma.

作者信息

Bomber P, McCready R, Hammersley P

出版信息

J Nucl Med. 1986 Feb;27(2):243-5.

PMID:3712042

Abstract

The effect of propranolol hydrochloride on the blood perfusion of a mouse sarcoma and other tissues has been studied using 86Rb. The maximum increase in relative tumor perfusion (2x controls) occurred 15 min after an i.v. administration of 10 mg per kg propranolol hydrochloride. To study the effect of this drug on the uptake of 67Ga, it was injected at a concentration of 10 mg/kg 10 min before administering 3 microCi (110 kBq) [67Ga]citrate. Tissue uptakes were measured 4 hr later. The tumor: blood ratio increased from 1.16 +/- 0.17 to 3.41 +/- 2.27 (s.d.) and tumor: liver ratio increased from 2.39 +/- 0.30 to 7.13 +/- 3.52 (s.d.). The results showed that propranolol hydrochloride can improve the relative tumor blood flow and radiopharmaceutical concentration in an animal model. It is hoped that this and other agents will yield similar results in the human situation.

摘要

已使用⁸⁶Rb研究了盐酸普萘洛尔对小鼠肉瘤及其他组织血液灌注的影响。静脉注射每千克10毫克盐酸普萘洛尔后15分钟，相对肿瘤灌注出现最大增幅（为对照组的2倍）。为研究该药物对⁶⁷Ga摄取的影响，在注射3微居里（110千贝克勒尔）枸橼酸[⁶⁷Ga]前10分钟，以每千克10毫克的浓度注射该药物。4小时后测量组织摄取情况。肿瘤与血液的比值从1.16±0.17增至3.41±2.27（标准差），肿瘤与肝脏的比值从2.39±0.30增至7.13±3.52（标准差）。结果表明，在动物模型中盐酸普萘洛尔可改善相对肿瘤血流及放射性药物浓度。希望该药物及其他药物在人体中也能产生类似结果。