Garel J R, Job D, Margolis R L
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3599-603. doi: 10.1073/pnas.84.11.3599.
We propose a motility mechanism that may result in the displacement of objects within the cell. The mechanism, which we call polymer-guided diffusion, involves a microscopic cycle of polymer association and dissociation from a lateral binding site. Reassociation occurs at the polymer subunit adjacent to that which has just dissociated, thus generating an apparent sliding movement. The displacement involves only free diffusion and the spontaneous fluctuations of the polymer; the movement thus requires no other energy sources than thermal energy and the energy originally required for the formation of the polymer. In this manner polymer-associated organelles can be guided (inevitably) by diffusional processes toward a final destination. The specific example of the anaphase movement of chromosomes poleward is detailed.
我们提出了一种可能导致细胞内物体位移的运动机制。我们将这种机制称为聚合物引导扩散，它涉及聚合物与侧向结合位点的微观结合和解离循环。重新结合发生在与刚解离的亚基相邻的聚合物亚基处，从而产生明显的滑动运动。这种位移仅涉及聚合物的自由扩散和自发波动；因此，该运动除了热能和聚合物形成最初所需的能量外，不需要其他能量来源。通过这种方式，与聚合物相关的细胞器可以（不可避免地）通过扩散过程被引导至最终目的地。文中详细阐述了染色体向极后期运动的具体例子。
