衰老可以通过利用秀丽隐杆线虫的长寿品系，从基因角度剖析为各个组成过程。
Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.
作者信息
Johnson T E
出版信息
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3777-81. doi: 10.1073/pnas.84.11.3777.
Abstract
The aging process has been dissected by analysis of genetic variants of the nematode Caenorhabditis elegans. Long-lived recombinant inbred lines were generated; some of these lines have mean and maximum life spans up to 70% longer than wild type. Longer life results from a slowing of the characteristic exponential increase in mortality rate that is typical of aging populations in all species. The length of developmental periods and the length of the reproductive period are unrelated to increased life span. Lengthened life is due entirely to an increase in postreproductive life span. Development, reproduction, and life span are each under independent genetic control. General motor activity decays linearly with chronological age in all genotypes. The decay in general motor activity is correlated with and a predictor of life span, suggesting that both share at least one common rate-determining component.
摘要
通过对线虫秀丽隐杆线虫的基因变异进行分析，剖析了衰老过程。构建了寿命长的重组近交系；其中一些品系的平均寿命和最大寿命比野生型长70%。寿命延长是由于衰老群体中典型的死亡率特征性指数增长减缓。发育期的长度和生殖期的长度与寿命延长无关。寿命延长完全是由于生殖后期寿命的增加。发育、繁殖和寿命各自受独立的基因控制。在所有基因型中，一般运动活动随实际年龄呈线性下降。一般运动活动的下降与寿命相关且是寿命的一个预测指标，这表明两者至少共享一个共同的速率决定成分。
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