从 D-鸟苷到 L-鸟苷的手性构建了一种稳定的凝胶，可用于三维细胞培养。

Chirality from D-guanosine to L-guanosine shapes a stable gel for three-dimensional cell culture.

机构信息

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China.

Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing 400016, P. R. China.

出版信息

Chem Commun (Camb). 2021 Dec 3;57(96):12936-12939. doi: 10.1039/c9cc09911e.

DOI:10.1039/c9cc09911e

PMID:34734933

Abstract

It is proved that L-guanosine (L-G) as an enantiomer of D-guanosine (D-G) forms more stable gels than D-G, suggesting that alteration of chirality may be a new strategy for improving the lifetime stability of supramolecular hydrogels. Experiments for three-dimensional cell culture reveal that the L-G gel is a candidate for the extracellular matrix.

摘要

研究证明，L-鸟苷（L-G）作为 D-鸟苷（D-G）的对映异构体，形成的凝胶比 D-G 更稳定，这表明手性的改变可能是提高超分子水凝胶寿命稳定性的一种新策略。用于三维细胞培养的实验表明，L-G 凝胶是细胞外基质的候选材料。