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弯曲杆菌属中抗菌药物耐药性的流行情况:文献综述

Prevalence of antimicrobial resistance in Campylobacter spp.: A review of the literature.

作者信息

Bulajić Nina, Miljković-Selimović Biljana, Tambur Zoran, Kocić Branislava, Kalevski Katarina, Aleksić Ema

机构信息

1Military Medical Academy, Belgrade, Serbia.

2Faculty of Medicine, University of Niš, Niš, Serbia.

出版信息

Acta Microbiol Immunol Hung. 2021 Nov 1. doi: 10.1556/030.2021.01544.

Abstract

Campylobacter spp. are commensal organisms in the intestinal tract of food producing and companion animals. There is an increasing trend of human campylobacteriosis worldwide, including complicated cases that request treatment by antibiotics. Prevalence of resistance continually increases, especially to fluoroquinolones and tetracyclines. There are many reports on multiresistant strains of Campylobacter spp.In this work we present the available information about the prevalence and antimicrobial resistance of Campylobacter spp. worldwide, as well as studies from Serbia published in last two decades. Campylobacter strains isolated from animal samples in Serbia showed increased prevalence of antimicrobial resistance to all clinically relevant antibiotics. Preliminary data (2014-2019) from Reference laboratory for Campylobacter and Helicobacter at the Institute of Public Health of Niš, Serbia show high resistance rates to ciprofloxacin (90%) and to tetracycline (50%) but low resistance to erythromycin (<5%) in human Campylobacter isolates.

摘要

弯曲杆菌属是食用动物和伴侣动物肠道中的共生生物。全球人类弯曲杆菌病呈上升趋势,包括需要使用抗生素治疗的复杂病例。耐药性的发生率持续上升,尤其是对氟喹诺酮类和四环素类药物。有许多关于弯曲杆菌属多重耐药菌株的报道。在这项工作中,我们展示了全球弯曲杆菌属的流行情况和抗菌药物耐药性的现有信息,以及塞尔维亚在过去二十年发表的研究。从塞尔维亚动物样本中分离出的弯曲杆菌菌株对所有临床相关抗生素的耐药性发生率有所增加。塞尔维亚尼什公共卫生研究所弯曲杆菌和幽门螺杆菌参考实验室的初步数据(2014 - 2019年)显示,人类弯曲杆菌分离株对环丙沙星(90%)和四环素(50%)的耐药率较高,但对红霉素的耐药率较低(<5%)。

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