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塞尔维亚首例由[未提及具体病因]引起的霉菌性腹主动脉瘤病例报告。

First Case Report of Mycotic Abdominal Aortic Aneurysm Caused by in Serbia.

作者信息

Medic Deana, Devrnja Milica, Batinic Nikola, Milosevic Djordje, Colovic Popadic Aleksandra, Gusman Vera

机构信息

Department of Microbiology with Parasitology and Immunology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.

Institute of Public Health of Vojvodina, Center for Microbiology, 21000 Novi Sad, Serbia.

出版信息

Pathogens. 2024 Sep 17;13(9):805. doi: 10.3390/pathogens13090805.

Abstract

BACKGROUND

Due to its distinct vascular tropism, is recognized as a significant cause of severe systemic infections, especially in immunocompromised individuals, while it is rarely reported as a cause of gastrointestinal infections.

METHODS

A rare case of mycotic abdominal aortic aneurysm associated with detected on the aneurysm wall itself was described.

RESULTS

A 68-year-old male was admitted to the hospital due to severe abdominal pain. The patient was afebrile, hemodynamically stable with elevated C-reactive protein levels. A physical examination revealed a palpable, pulsatile, tender mass located in the periumbilical region. Ultrasonography and multi-slice computer tomography angiography (MSCTA) identified an infrarenal abdominal aortic aneurysm with a maximum diameter of 6.5 cm, showing suspicious signs of dissection. Aneurysmectomy with Dacron tube graft interposition was performed. Although the blood cultures remained negative, the culture of the aneurysmal wall grew , enabling early diagnosis and targeted antibiotic therapy. The patient was treated with meropenem for two weeks, followed by amoxicillin-clavulanate for another two weeks after hospital discharge.

CONCLUSIONS

associated with abdominal aortic aneurysms represents a life-threatening condition, posing a significant challenge in vascular surgery. Due to the lack of clear guidelines on antibiotic susceptibility testing and the treatment of infections associated with this pathogen, enhanced surveillance of is necessary in both human and veterinary medicine.

摘要

背景

因其独特的血管嗜性,被认为是严重全身感染的重要原因,尤其是在免疫功能低下的个体中,而作为胃肠道感染的原因则鲜有报道。

方法

描述了一例罕见的与在动脉瘤壁上检测到的相关的霉菌性腹主动脉瘤病例。

结果

一名68岁男性因严重腹痛入院。患者无发热,血流动力学稳定,C反应蛋白水平升高。体格检查发现脐周区域有一个可触及的、搏动性的、压痛性肿块。超声检查和多层螺旋计算机断层血管造影(MSCTA)发现一个肾下腹主动脉瘤,最大直径为6.5cm,显示有可疑的夹层迹象。进行了腹主动脉瘤切除术并植入涤纶人工血管。尽管血培养结果仍为阴性,但动脉瘤壁培养出了,从而实现了早期诊断和针对性抗生素治疗。患者接受美罗培南治疗两周,出院后再接受阿莫西林-克拉维酸治疗两周。

结论

与腹主动脉瘤相关的是一种危及生命的疾病,给血管外科带来了重大挑战。由于缺乏关于该病原体抗生素敏感性检测和感染治疗的明确指南,因此在人类医学和兽医学中都有必要加强对的监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/645a/11434686/d66fc99755f3/pathogens-13-00805-g001.jpg

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