species prevalence, characterisation of antimicrobial resistance and analysis of whole-genome sequence of isolates from livestock and humans, Latvia, 2008 to 2016.

Background is the main cause of bacterial gastroenteritis worldwide. The main transmission route is through consumption of food contaminated with species or contact with infected animals. In Latvia, the prevalence of campylobacteriosis is reported to be low (4.6 cases per 100,000 population in 2016).AimTo determine prevalence, species spectrum and antimicrobial resistance (AMR) of spp. in Latvia, using data from various livestock and human clinical samples.MethodsWe analysed data of microbiological monitoring and AMR (2008 and 2014-16) in Latvia. Data from broilers, poultry, pigs, calves and humans were used to determine prevalence of . Additionally, 45 different origin isolates (22 human) were sequenced on the Illumina MiSeq platform; for each isolate core genome multilocus sequence typing was used and relevant antimicrobial resistance mechanisms were identified.ResultsOverall, prevalence in was 83.3% in pigs, 50.2% in broilers, 16.1% in calves and 5.3% in humans; was the predominant species in all sources except pigs where was main species. High level of resistance in were observed against fluoroquinolones, tetracycline and streptomycin, in most of sequenced isolates genetic determinants of relevant AMR profiles were identified.ConclusionsIn Latvia, prevalence of in livestock is high, especially in pigs and broilers; prevalence in poultry and humans were lower than in other European countries. AMR analysis reveals increase of streptomycin and tetracycline resistant broiler origin strains. WGS demonstrates a high compliance between resistance phenotype and genotype for quinolones and tetracyclines.