Ishikawa Masaki, Hasebe Mitsuyasu
National Institute for Basic Biology, Okazaki, 444-8585, Japan; School of Life Science, The Graduate University for Advanced Studies, Okazaki, 444-8585, Japan.
Curr Opin Plant Biol. 2022 Feb;65:102123. doi: 10.1016/j.pbi.2021.102123. Epub 2021 Nov 1.
Plant and animal stem cells can self-renew and give rise to differentiated cells to form tissues or organs. Unlike differentiated cells in animals, those in land plants can be readily reprogrammed into stem cells, reflecting the plasticity of plant cell identity. The moss Physcomitrium patens (synonym: Physcomitrella patens) is highly regenerable, and its leaf cells can be reprogrammed into stem cells in response to wounding or by transient DNA damage without wounding. Wounding and DNA damage induce STEM CELL-INDUCING FACTOR 1, an APETALA2/ETHYLENE RESPONSE FACTOR. Here, we summarize the genetic networks that regulate cellular reprogramming in P. patens and the roles of STEMIN1 and discuss the generality and divergence of the molecular mechanisms underlying cellular reprogramming in land plants and animals.
植物和动物干细胞能够自我更新，并产生分化细胞以形成组织或器官。与动物的分化细胞不同，陆地植物中的分化细胞可以很容易地重编程为干细胞，这反映了植物细胞身份的可塑性。小立碗藓（同义词：小立碗藓）具有高度的再生能力，其叶细胞可以因受伤或在无伤口的情况下通过短暂的DNA损伤而重编程为干细胞。受伤和DNA损伤会诱导干细胞诱导因子1，这是一种APETALA2/乙烯反应因子。在这里，我们总结了调控小立碗藓细胞重编程的遗传网络以及STEMIN1的作用，并讨论了陆地植物和动物细胞重编程潜在分子机制的普遍性和差异。
