Faculty of Biology, Plant Cell Biology, Philipps University of Marburg, 35037 Marburg an der Lahn, Hesse, Germany
Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, Connecticut 06269.
Plant Cell. 2020 May;32(5):1361-1376. doi: 10.1105/tpc.19.00828. Epub 2020 Mar 9.
Since the discovery two decades ago that transgenes are efficiently integrated into the genome of by homologous recombination, this moss has been a premier model system to study evolutionary developmental biology questions, stem cell reprogramming, and the biology of nonvascular plants. was the first non-seed plant to have its genome sequenced. With this level of genomic information, together with increasing molecular genetic tools, a large number of reverse genetic studies have propelled the use of this model system. A number of technological advances have recently opened the door to forward genetics as well as extremely efficient and precise genome editing in Additionally, careful phylogenetic studies with increased resolution have suggested that emerged from within Thus, rather than , the species should be named Here we review these advances and describe the areas where has had the most impact on plant biology.
自二十年前发现转基因能够通过同源重组有效地整合到 的基因组中以来，这种苔藓一直是研究进化发育生物学问题、干细胞重编程和非维管束植物生物学的主要模式系统。 是第一个基因组测序的非种子植物。有了这种基因组信息水平，再加上越来越多的分子遗传工具，大量的反向遗传学研究推动了这种模式系统的应用。最近，一些技术进步为正向遗传学以及 的高效和精确基因组编辑打开了大门。此外，分辨率提高的仔细系统发育研究表明， 是从 内部进化而来的。因此，与其说 是一个独立的物种，不如说它应该被命名为 。在这里，我们回顾这些进展，并描述 在植物生物学中最有影响力的领域。
