Nrf2：虾青素的分子治疗靶点。
Nrf2 a molecular therapeutic target for Astaxanthin.
机构信息
Department of Biology, Faculty of Sciences, University of Tehran, Iran.
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran; Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
出版信息
Biomed Pharmacother. 2021 May;137:111374. doi: 10.1016/j.biopha.2021.111374. Epub 2021 Feb 18.
Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic and anti-proliferative properties. In the present review, we discuss the role of Nrf2 in mediating the anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective, hepatoprotective, anti-diabetic and muscloprotective effects of ATX.
虾青素（ATX）是一种存在于虾、三文鱼、蟹和海星中的红色类胡萝卜素色素。多项研究证实了 ATX 的抗氧化功效。此外，ATX 还具有抗炎、抗细胞凋亡和抗增殖作用。在本综述中，我们讨论了 Nrf2 在介导 ATX 的抗癌、抗衰老、神经保护、肺保护、皮肤保护、心脏保护、肝脏保护、抗糖尿病和肌肉保护作用中的作用。
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