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虾青素及其在炎症反应和炎症相关疾病中的作用：最新进展和未来方向。

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions.

机构信息

State Key Laboratory of Freshwater Ecology and Biotechnology, Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan 430072, China.

出版信息

Molecules. 2020 Nov 16;25(22):5342. doi: 10.3390/molecules25225342.

DOI:10.3390/molecules25225342
PMID:33207669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7696511/
Abstract

Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin has gained growing interest as a multi-target pharmacological agent against various diseases. In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described. Furthermore, the applications of anti-inflammatory effects of astaxanthin in neurological diseases, diabetes, gastrointestinal diseases, hepatic and renal diseases, eye and skin disorders, are highlighted. In addition to the protective effects of astaxanthin in various chronic and acute diseases, we also summarize recent advances for the inconsistent roles of astaxanthin in infectious diseases, and give our view that the exact function of astaxanthin in response to different pathogen infection and the potential protective effects of astaxanthin in viral infectious diseases should be important research directions in the future.

摘要

虾青素是一种天然的脂溶性、红橙色类胡萝卜素。由于其强大的抗氧化、抗炎、抗凋亡和免疫调节特性，虾青素作为一种针对多种疾病的多靶点药理制剂，引起了越来越多的关注。在本综述中，描述了虾青素针对炎症生物标志物和多种信号通路（包括 PI3K/AKT、Nrf2、NF-κB、ERK1/2、JNK、p38 MAPK 和 JAK-2/STAT-3）的抗炎机制。此外，还强调了虾青素在神经退行性疾病、糖尿病、胃肠道疾病、肝和肾疾病、眼和皮肤疾病中的抗炎作用的应用。除了虾青素在各种慢性和急性疾病中的保护作用外，我们还总结了最近关于虾青素在传染病中不一致作用的研究进展，并认为虾青素在应对不同病原体感染时的确切功能以及虾青素在病毒性传染病中的潜在保护作用应该是未来的重要研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec12/7696511/e64a97b361c0/molecules-25-05342-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec12/7696511/8d9d9c07a538/molecules-25-05342-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec12/7696511/e64a97b361c0/molecules-25-05342-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec12/7696511/8d9d9c07a538/molecules-25-05342-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec12/7696511/e64a97b361c0/molecules-25-05342-g002.jpg

相似文献

[1]
Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions.

Molecules. 2020-11-16

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Astaxanthin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Repairing the Intestinal Barrier, Regulating Specific Intestinal Flora, and Reducing Inflammatory Cell Infiltration.

J Immunol Res. 2025-8-21

[2]
Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats.

Sci Rep. 2025-9-1

[3]
Skin Aging and Carotenoids: A Systematic Review of Their Multifaceted Protective Mechanisms.

Nutrients. 2025-8-9

[4]
The Effect of Astaxanthin on Ochratoxin A-Induced Intestinal Injury in Chickens Through RIPK1/RIPK3/MLKL Pathway.

Antioxidants (Basel). 2025-7-25

[5]
The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial.

Front Pharmacol. 2025-8-7

[6]
Comparative Analysis of the Antioxidant and Anti-Inflammatory Effects of Krill and Fish Oil.

Int J Mol Sci. 2025-7-30

[7]
Functional Recovery Promotion After Spinal Cord Injury With Astaxanthin Treatment in Preclinical Studies: A Systematic Review and Meta-Analysis.

Neurol Res Int. 2025-8-1

[8]
An overview of current research on the modulation of NLRP3 inflammasome by traditional Chinese medicine to combat acute pancreatitis.

Front Mol Biosci. 2025-7-16

[9]
Nano Astaxanthin ameliorates myocardial infarction in rats through autophagy.

Sci Rep. 2025-6-20

[10]
Astaxanthin supplementation mitigated intestinal damage and immunity in overfed Pekin ducks by regulating gut morphology, intestinal inflammation, and antioxidant balance.

Anim Nutr. 2025-1-16

本文引用的文献

[1]
Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications.

Food Chem Toxicol. 2020-11

[2]
Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations.

Cells. 2020-8-24

[3]
Docosahexaenoic acid-acylated astaxanthin ester exhibits superior performance over non-esterified astaxanthin in preventing behavioral deficits coupled with apoptosis in MPTP-induced mice with Parkinson's disease.

Food Funct. 2020-9-23

[4]
Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications.

Mar Drugs. 2020-7-9

[5]
Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention.

Toxicol Rep. 2020-6-18

[6]
Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro.

J Cell Mol Med. 2020-8

[7]
The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo.

Exp Eye Res. 2020-8

[8]
Protective effect of high-affinity liposomes encapsulating astaxanthin against corneal disorder in the rat dry eye disease model.

J Clin Biochem Nutr. 2020-5

[9]
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

Cell. 2020-5-15

[10]
Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis.

Neurosci Res. 2021-4

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