Mackie I A, Seal D V
Scand J Rheumatol Suppl. 1986;61:220-3.
The diagnosis of moderate degrees of tear depletion is difficult using conventional tests such as the Schirmer test, clinical evidence and even a confirmatory test such as the lysozyme test. We have refined the lysozyme test using quantitative techniques and calibrated standards. We found this satisfactory on a population basis, but not on an individual basis. We developed an ELISA test for assaying five tear proteins 'lysozyme, lactoferrin, ceruloplasmin, IgA and IgG' which gives a much more accurate assessment of dryness on an individual patient level.
使用传统测试（如泪液分泌试验、临床证据甚至是溶菌酶试验等确证性测试）来诊断中度泪液缺乏是困难的。我们使用定量技术和校准标准改进了溶菌酶试验。我们发现，从总体人群角度来看这是令人满意的，但从个体角度并非如此。我们开发了一种酶联免疫吸附测定（ELISA）试验，用于检测五种泪液蛋白（溶菌酶、乳铁蛋白、铜蓝蛋白、免疫球蛋白A和免疫球蛋白G），该试验能在个体患者层面上对眼干情况给出更准确的评估。
