Payandeh Zahra, Pirpour Tazehkand Abbas, Azargoonjahromi Ali, Almasi Faezeh, Alagheband Bahrami Armina
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biol Proced Online. 2021 Nov 4;23(1):20. doi: 10.1186/s12575-021-00158-4.
Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted.
在富裕国家，自身免疫性疾病累及至少25%的人口。包括遗传、表观遗传和环境因素在内的多种因素与类风湿关节炎作为一种自身免疫性疾病的发展有关。自身抗体导致滑膜炎症和关节炎，如果不治疗或持续受到外部刺激，可能会导致慢性炎症、关节损伤和残疾。T细胞和B细胞、信号分子、促炎介质以及滑膜特异性靶点是新的治疗靶点。外泌体可作为治疗自身免疫性疾病的治疗载体。本文讨论了细胞器尤其是外泌体在类风湿关节炎中的作用，并强调了外泌体的一些治疗应用。
