Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Flowcyt Science-Based Company, Tehran, Iran.
Department of Immunology, Bu-Ali Research Institute, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Autoimmun Rev. 2020 Jun;19(6):102511. doi: 10.1016/j.autrev.2020.102511. Epub 2020 Mar 12.
Rheumatoid arthritis is a well-known chronic inflammatory joint disorder. It encompasses systemic inflammation, autoimmunity and development of several joint abnormalities leading to the lifelong disability and increased mortality. Exosomes are nano-sized (30-100 nm) mammalian extracellular particles with essential properties to regulate biological processes and cellular signaling by transferring protein and genetic materials. Understanding the diversity in the exosomal contents and their corresponding targets may contribute to better recognition of the processes that are implicated in the development and progression of diseases such as autoimmune disorders. Exosomes may act as a potential biomarker for the diagnosis of autoimmune disorders. In the present review, we aimed to bring together the relevant evidence on the biology of exosomes in rheumatoid arthritis, and also discuss the recent findings regarding the diagnostic, prognostic and therapeutic promise of these nanoparticles.
类风湿关节炎是一种众所周知的慢性炎症性关节疾病。它包括全身炎症、自身免疫和几种关节异常的发展，导致终身残疾和死亡率增加。外泌体是纳米大小（30-100nm）的哺乳动物细胞外颗粒，具有通过传递蛋白质和遗传物质来调节生物过程和细胞信号的重要特性。了解外泌体内容物的多样性及其相应的靶标可能有助于更好地认识到自身免疫性疾病等疾病发展和进展过程中涉及的过程。外泌体可能是自身免疫性疾病诊断的潜在生物标志物。在本综述中，我们旨在汇集有关类风湿关节炎中外泌体生物学的相关证据，并讨论关于这些纳米颗粒在诊断、预后和治疗方面的最新发现。
