Cologne Merheim Hospital, Department of Pneumology, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne and Witten, North Rhine-Westphalia, Germany.
Int J Chron Obstruct Pulmon Dis. 2021 Oct 28;16:2963-2971. doi: 10.2147/COPD.S328404. eCollection 2021.
To assess the influence of anemia on health-related quality of life (HRQL) in COPD patients receiving long-term non-invasive ventilation (NIV).
In this prospective single-center cohort study, COPD patients on long-term NIV were analyzed between June 2015 and May 2020. Linear multiple regression analyses were performed using the results of the Severe Respiratory Insufficiency Questionnaire (SRI) along with the following variables: sex, age, body mass index, duration of NIV, exacerbation history (≤1 versus >1 in the previous year), the updated Charlson comorbidity index, hemoglobin levels and anemia (WHO criteria).
Anemia was identified in 32.8% (N=128). Anemia (mean difference -8.4, 95% CI -2.0/-14.9 SRI points, =0.011) and exacerbations (mean difference -9.9, 95% CI -4.3/-15.5 SRI points, =0.001) each had a negative impact on SRI summary scores. Exacerbations were negatively associated with six out of seven SRI subscale scores, while anemia was negatively associated with four out of seven. SRI summary scores dropped by 1.5 points for every g/dl of hemoglobin (=0.08). No other variables had an influence on the SRI scores.
The present study has shown that within a cohort of COPD patients undergoing long-term NIV, one-third were identified as anemic. Furthermore, anemia, like exacerbation history, was found to have a considerable negative impact on HRQL that is specific to patients with chronic respiratory failure.
German Clinical Trials Registry (DRKS00008759).
评估贫血对接受长期无创通气（NIV）的 COPD 患者健康相关生活质量（HRQL）的影响。
在这项前瞻性单中心队列研究中，分析了 2015 年 6 月至 2020 年 5 月期间接受长期 NIV 的 COPD 患者。使用严重呼吸衰竭问卷（SRI）的结果以及以下变量进行线性多回归分析：性别、年龄、体重指数、NIV 持续时间、加重病史（前一年≤1 次与>1 次）、更新的 Charlson 合并症指数、血红蛋白水平和贫血（WHO 标准）。
32.8%（N=128）存在贫血。贫血（平均差异-8.4，95%CI-2.0/-14.9 SRI 点，=0.011）和加重（平均差异-9.9，95%CI-4.3/-15.5 SRI 点，=0.001）对 SRI 综合评分均有负面影响。加重与 SRI 七个亚量表评分中的六个呈负相关，而贫血与七个中的四个呈负相关。血红蛋白每下降 1g/dl，SRI 综合评分下降 1.5 分（=0.08）。其他变量对 SRI 评分均无影响。
本研究表明，在接受长期 NIV 的 COPD 患者队列中，有三分之一的患者被诊断为贫血。此外，贫血与加重病史一样，对慢性呼吸衰竭患者的 HRQL 有相当大的负面影响。
德国临床试验注册处（DRKS00008759）。
