Respiratory Department, Hospital Galdakao-Usansolo, Galdakao, Bizkaia, Spain.
Health Services Research on Chronic Patients Network (REDISSEC), Galdakao, Bizkaia, Spain.
Respir Res. 2020 Jun 5;21(1):138. doi: 10.1186/s12931-020-01395-z.
Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated with HRQoL and whether they continue to have an influence in the medium term, during follow-up.
Overall, 543 patients with COPD were included in this prospective observational longitudinal study. At all four visits during a 5-year follow-up, the patients completed the Saint George's Respiratory Questionnaire (SGRQ), pulmonary function tests, the 6-min walk test (6MWT), and a physical activity (PA) questionnaire, among others measurements. Data on hospitalization for COPD exacerbations and comorbidities were retrieved from the personal electronic clinical record of each patient at every visit.
The best fit to the data of the cohort was obtained with a beta-binomial distribution. The following variables were related over time to SGRQ components: age, inhaled medication, smoking habit, forced expiratory volume in one second, handgrip strength, 6MWT distance, body mass index, residual volume, diffusing capacity of the lung for carbon monoxide, PA (depending on level, 13 to 35% better HRQoL, in activity and impacts components), and hospitalizations (5 to 45% poorer HRQoL, depending on the component).
Among COPD patients, HRQoL was associated with the same variables throughout the study period (5-year follow-up), and the variables with the strongest influence were PA and hospitalizations.
健康相关生活质量（HRQoL）应被视为一种工具，提供 COPD 患者一般临床状况的整体视图。本研究的目的是确定与 HRQoL 相关的变量，以及它们在随访期间的中期是否仍有影响。
本前瞻性观察性纵向研究共纳入 543 例 COPD 患者。在 5 年随访的所有 4 次就诊中，患者完成了圣乔治呼吸问卷（SGRQ）、肺功能测试、6 分钟步行测试（6MWT）和体力活动（PA）问卷等测量。在每次就诊时，从每位患者的个人电子临床记录中检索与 COPD 加重和合并症相关的数据。
队列数据的最佳拟合是β二项式分布。以下变量与 SGRQ 各成分随时间相关：年龄、吸入药物、吸烟习惯、一秒用力呼气量、握力、6MWT 距离、体重指数、残气量、一氧化碳弥散量、PA（取决于水平，活动和影响成分提高 13%至 35%的 HRQoL）和住院治疗（取决于成分，HRQoL 降低 5%至 45%）。
在 COPD 患者中，HRQoL 在整个研究期间（5 年随访）与相同的变量相关，影响最大的变量是 PA 和住院治疗。
