Qi Hengxin, Pan Yuefeng, Chen Li, Li Rui, Wang Chonghua, Wang Ruimin
Department of Imaging, Zhangqiu District People's Hospital, Jinan, China.
Department of Imaging, People's Hospital of Rizhao, Rizhao, China.
Evid Based Complement Alternat Med. 2021 Oct 26;2021:1124526. doi: 10.1155/2021/1124526. eCollection 2021.
This study aimed to investigate the effects of traditional Chinese medicine (TCM) on biological behavior and magnetic resonance imaging and recurrence rate of patients with bladder cancer.
Forty-seven postoperative bladder cancer patients treated in our hospital who met the criteria were selected and randomly divided into the TCM treatment group (observation group) and the group without TCM treatment (control group). In the TCM treatment group, the prescription was slightly adjusted according to the different symptoms, and the main prescription remained unchanged. According to the treatment plan, patients continued to undergo bladder irrigation chemotherapy plus TCM treatment, while the control group was only treated with bladder irrigation chemotherapy. The number of patients with recurrence at 3 and 6 months and 1 year, the effects on patients' clinical symptoms, and quality of life were observed, respectively. The changes in MRI images, blood routine, immune function, and leukocyte level and other related indexes before and after treatment were compared between the two groups.
After the patients in the observation group were treated with traditional Chinese medicine, the patients' quality of life significantly improved. The patients' CD3+, CD4+, and CD4+/CD8+ indexes were significantly higher than those of the control group. The levels of Hb and PLT of the patients in the observation group were significantly lower than those of the patients in the control group. Patients in the observation group had higher leukocyte levels and a lower recurrence rate than patients in the control group.
TCM with chemotherapy drugs can effectively improve patients' immune function, increase the level of T-lymphocyte subpopulation, and improve bone marrow hematopoietic function, which has a significant effect on the prevention and treatment of bladder cancer recurrence after surgery.
本研究旨在探讨中药对膀胱癌患者生物学行为、磁共振成像及复发率的影响。
选取我院收治的47例符合标准的膀胱癌术后患者，随机分为中药治疗组（观察组）和未进行中药治疗组（对照组）。中药治疗组根据不同症状微调方剂，主方不变。按照治疗方案，患者继续接受膀胱灌注化疗加中药治疗，而对照组仅接受膀胱灌注化疗。分别观察3个月、6个月及1年时的复发患者数量、对患者临床症状的影响以及生活质量。比较两组治疗前后MRI图像、血常规、免疫功能、白细胞水平等相关指标的变化。
观察组患者经中药治疗后，生活质量显著改善。患者的CD3 +、CD4 +及CD4 +/CD8 +指标显著高于对照组。观察组患者的Hb和PLT水平显著低于对照组患者。观察组患者的白细胞水平高于对照组，复发率低于对照组。
中药联合化疗药物可有效提高患者免疫功能，增加T淋巴细胞亚群水平，改善骨髓造血功能，对膀胱癌术后复发的防治有显著作用。
