Aljuaid Sattam M, Mirza Ahmad A, Habib Lura A, AlHarthi Lujain A, Alansari Bashayer M, AlQahtani Bashaier G, Althobaiti Youssef A
Department of Otolaryngology, Head and Neck Surgery, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia.
Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
Int Arch Otorhinolaryngol. 2020 Nov 30;25(4):e628-e632. doi: 10.1055/s-0040-1718965. eCollection 2021 Oct.
Excessive caffeine intake has been thought to be a contributory factor for tinnitus. However, there has been no systematic review to elucidate the causal relationship between caffeine intake and the incidence of tinnitus. We performed the current review aiming at evaluating the evidence from the current literature for the relationship between caffeine intake and the incidence of tinnitus. Databases including PubMed, Scopus, and Google scholar were searched for relevant articles. A total of 142 studies were screened for eligibility, of which four articles met our inclusion criteria: two were prospective cohorts and two were cross-sectional studies. Although one study found no association between caffeine consumption and the incidence of tinnitus, an inverse relationship was reported by two population-based studies. Concerning patients with preexisting tinnitus, reduction of caffeine intake in a subset who consumed 150 ml to 300 ml/day of coffee yielded a favorable outcome in tinnitus severity. However, those with higher dose intake were less prone to have improvement in the severity of tinnitus. Although the current review was inconclusive, it appears that the incidence of tinnitus in previously unaffected individuals might be prevented by a high dose of caffeine intake. However, in preexisting tinnitus, a high dose of caffeine may adversely interfere with the efficacy of caffeine reduction.
过量摄入咖啡因一直被认为是导致耳鸣的一个因素。然而，目前尚无系统评价来阐明咖啡因摄入与耳鸣发病率之间的因果关系。
我们进行了本次综述，旨在评估现有文献中关于咖啡因摄入与耳鸣发病率关系的证据。
检索了包括PubMed、Scopus和谷歌学术在内的数据库以查找相关文章。总共筛选了142项研究以确定其是否符合条件，其中有4篇文章符合我们的纳入标准：2篇为前瞻性队列研究，2篇为横断面研究。尽管有一项研究发现咖啡因消费与耳鸣发病率之间无关联，但两项基于人群的研究报告了相反的关系。对于已有耳鸣的患者，在每天饮用150毫升至300毫升咖啡的一部分患者中减少咖啡因摄入量，耳鸣严重程度有良好改善。然而，摄入量较高的患者耳鸣严重程度改善的可能性较小。
尽管本次综述尚无定论，但似乎高剂量摄入咖啡因可能会预防先前未受影响个体的耳鸣发病率。然而，对于已有耳鸣的情况，高剂量咖啡因可能会对减少咖啡因摄入的效果产生不利干扰。
