School of Public Health, Qingdao University, Qingdao, Shandong, China.
Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Dis Markers. 2021 Oct 26;2021:8554844. doi: 10.1155/2021/8554844. eCollection 2021.
Fumarate hydratase (FH) is an important enzymatic component in the tricarboxylic acid cycle. Studies have reported that FH plays an important role in hereditary leiomyomatosis and renal cell cancer (HLRCC). However, the role of FH in human different cancers remains unknown. This study is aimed at analyzing the prognostic value of FH and demonstrating the correlation between FH expression and tumor immunity. Results showed that FH was mutated or copy number varied in 27 types of cancer. FH mRNA was abnormally upregulated across various cancers. Survival analysis suggested high expression of FH was associated with poor prognosis in many cancer types, including lung adenocarcinoma (LUAD). Additionally, FH expression was associated with immune infiltration, including B cells, CD4 T cells, CD8 T cells, neutrophils, macrophages, and dendritic cells, especially in liver hepatocellular carcinoma (LIHC), LUAD, and lung squamous cell carcinoma (LUSC). Moreover, FH expression showed a strong correlation with immune checkpoint markers in LUAD and testicular germ cell tumors (TGCT). These results indicate that FH is an immunotherapeutic target and a potential prognostic biomarker in LUAD.
延胡索酸水合酶（FH）是三羧酸循环中的一个重要酶成分。研究表明，FH 在遗传性平滑肌瘤病和肾细胞癌（HLRCC）中发挥着重要作用。然而，FH 在人类不同癌症中的作用尚不清楚。本研究旨在分析 FH 的预后价值，并展示 FH 表达与肿瘤免疫之间的相关性。结果表明，FH 在 27 种癌症中发生了突变或拷贝数改变。FH mRNA 在各种癌症中异常上调。生存分析表明，FH 的高表达与多种癌症类型的不良预后相关，包括肺腺癌（LUAD）。此外，FH 表达与免疫浸润有关，包括 B 细胞、CD4 T 细胞、CD8 T 细胞、中性粒细胞、巨噬细胞和树突状细胞，尤其是在肝肝细胞癌（LIHC）、LUAD 和肺鳞状细胞癌（LUSC）中。此外，在 LUAD 和睾丸生殖细胞肿瘤（TGCT）中，FH 表达与免疫检查点标志物呈强相关性。这些结果表明，FH 是 LUAD 中的一种免疫治疗靶点和潜在的预后生物标志物。
