Suppr超能文献

基于数学模型分析的磁共振成像对茶氨酸治疗脑缺血再灌注损伤作用的动态观察。

Dynamic Observation of the Effect of L-Theanine on Cerebral Ischemia-Reperfusion Injury Using Magnetic Resonance Imaging under Mathematical Model Analysis.

机构信息

Renmin Hospital of Wuhan University, Department of Neurosurgery, Wuhan, Hubei 430060, China.

出版信息

J Healthc Eng. 2021 Oct 26;2021:5679665. doi: 10.1155/2021/5679665. eCollection 2021.

Abstract

This study was to use the partial differential mathematical model to analyze the magnetic resonance imaging (MRI) images of cerebral ischemia-reperfusion injury (CIRI) and to dynamically observe the role of L-theanine in CIRI based on this. 30 patients with cerebral ischemia in a hospital in a certain area were selected and divided into a cerebral ischemia group and a L-theanine treatment group. The two groups of patients were examined by MRI within 48 hours, and the relative apparent diffusion coefficient (rADC) of the cerebral ischemic part of the patients was determined. The partial differential mathematical model was used for data processing to obtain the function of cerebral ischemia time and infarct area, and the data of patients in the cerebral ischemia group and L-theanine treatment group were compared and analyzed. The results showed that the partial differential mathematical model could effectively analyze the linear relationship between the rADC value and time in the treatment of CIRI using L-theanine. The rADC values of the four points of interest in the L-theanine treatment group all increased with time, and there was a positive correlation between the variables and . In observing the efficacy indicators of L-theanine, the L-theanine treatment group showed a significant advantage in the neurospecific enolase (NSE) content compared with the cerebral ischemia group ( < 0.01), and the neurological function score of the L-theanine treatment group gradually decreased and showed a statistically obvious difference on the 7 day of treatment ( < 0.05). In summary, it was verified in this study that the role of L-theanine in the treatment of CIRI was of a great and positive significance for the subsequent treatment of patients with cerebral ischemia, providing reliable theoretical basis and data basis for clinical treatment of CIRI.

摘要

本研究旨在使用偏微分数学模型分析脑缺血再灌注损伤(CIRI)的磁共振成像(MRI)图像,并基于此动态观察茶氨酸在 CIRI 中的作用。选取某地区医院的 30 例脑缺血患者,分为脑缺血组和茶氨酸治疗组。两组患者均在 48 小时内进行 MRI 检查,测定患者脑缺血部位的相对表观扩散系数(rADC)。使用偏微分数学模型对数据进行处理,得到脑缺血时间和梗死面积的函数,对比分析脑缺血组和茶氨酸治疗组患者的数据。结果表明,偏微分数学模型可以有效分析茶氨酸治疗 CIRI 时 rADC 值与时间的线性关系。茶氨酸治疗组的四个观察点的 rADC 值随时间增加而增加,变量 和 之间呈正相关。在观察茶氨酸的疗效指标时,茶氨酸治疗组的神经特异性烯醇化酶(NSE)含量与脑缺血组相比具有显著优势(<0.01),茶氨酸治疗组的神经功能评分在治疗第 7 天逐渐下降,且差异具有统计学意义(<0.05)。综上所述,本研究验证了茶氨酸在治疗 CIRI 中的作用,对脑缺血患者的后续治疗具有重要的积极意义,为 CIRI 的临床治疗提供了可靠的理论依据和数据基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b55c/8563127/65d292992ab5/JHE2021-5679665.001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验