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关节内注射自体条件血清治疗膝骨关节炎的有效性：一项荟萃分析研究。

Effectiveness of intra-articular autologous-conditioned serum injection in knee osteoarthritis: a meta-analysis study.

作者信息

Raeissadat Seyed A, Rayegani Seyed M, Sohrabi Mohammad R, Jafarian Nafisseh, Bahrami Mohammad N

机构信息

Physiatrist, Associate Professor, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Physiatrist, Professor, Physical Medicine & Rehabilitation Department & Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Future Sci OA. 2021 Oct 11;7(9):FSO759. doi: 10.2144/fsoa-2021-0069. eCollection 2021 Oct.

DOI:10.2144/fsoa-2021-0069
PMID:34737891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8558851/
Abstract

AIM

Knee osteoarthritis is a common disabling disorder, with no curative treatment. This study aims to assess autologous conditioned serum effectiveness in its treatment.

MATERIALS & METHODS: Following a systematic search (2000-2020) on major databases and screening and filtering processes, eight articles were included in the final analyses. The pooled effect of visual analog scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) variables was evaluated before and after the intervention.

RESULTS

The combined standardized mean difference for the global WOMAC score was -2.44 and the combined weighted mean difference was -22.92. The combined standardized mean difference for the VAS score was -3.77 and the combined weighted mean difference was -32.37 (p < 0.000).

CONCLUSION

This meta-analysis reported that the autologous conditioned serum can reduce pain and improve function (VAS and WOMAC outcome measures) in patients with knee osteoarthritis.

摘要

目的

膝关节骨关节炎是一种常见的致残性疾病，尚无治愈方法。本研究旨在评估自体浓缩血清治疗该病的有效性。

材料与方法

在对主要数据库进行系统检索（2000 - 2020年）以及筛选和过滤流程后，最终分析纳入了8篇文章。在干预前后评估视觉模拟量表（VAS）以及西安大略和麦克马斯特大学骨关节炎指数（WOMAC）变量的合并效应。

结果

全球WOMAC评分的合并标准化平均差为 -2.44，合并加权平均差为 -22.92。VAS评分的合并标准化平均差为 -3.77，合并加权平均差为 -32.37（p < 0.000）。

结论

该荟萃分析表明，自体浓缩血清可减轻膝关节骨关节炎患者的疼痛并改善功能（VAS和WOMAC结局指标）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/9c06cde62a72/fsoa-07-759-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/6cfe8d540ac3/fsoa-07-759-g1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/ae6166f93e5d/fsoa-07-759-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/fe2f83ad9468/fsoa-07-759-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/7ca875d7e8c7/fsoa-07-759-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/6d7b367c154f/fsoa-07-759-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/9c06cde62a72/fsoa-07-759-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/6cfe8d540ac3/fsoa-07-759-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/eec9b91302a3/fsoa-07-759-g2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/ae6166f93e5d/fsoa-07-759-g4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/7ca875d7e8c7/fsoa-07-759-g6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32de/8558851/9c06cde62a72/fsoa-07-759-g8.jpg

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