Yang Chun-Qi, Lian Wen-Yu, Wang Yu-Guang, Gao Yue
Anhui Medical University Hefei 230032, China Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences Beijing 100850, China.
Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences Beijing 100850, China Guangdong Pharmaceutical University Guangzhou 510006, China.
Zhongguo Zhong Yao Za Zhi. 2021 Oct;46(20):5218-5225. doi: 10.19540/j.cnki.cjcmm.20210518.602.
Evodiamine, a bioactive indole alkaloid from Evodia rutaecarpa, E. rutaecarpa var. officinalis, or E. rutaecarpa var. bodinieri, has been extensively investigated due to its pharmacological activities in recent years. At present, evodiamine is proved to significantly suppress the proliferation of a variety of cancer cells and mediate cell processes such as cell cycle arrest and cell migration. In addition, evodiamine displays significant pharmacological activities against cardiovascular diseases(hyperlipidemia, etc.), and tinea manus and pedis. Recently, evodiamine has been found to have potential toxic effects, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. However, the pharmacological and toxicological mechanism of evodiamine is not clear, and its toxicity in vitro and in vivo has been rarely reported. Therefore, this study reviewed the pharmacological and toxicological articles of evodiamine in recent years, aiming at providing new ideas and references for future research.
吴茱萸碱是一种从吴茱萸、吴茱萸变种或吴茱萸变种中提取的具有生物活性的吲哚生物碱，近年来因其药理活性受到广泛研究。目前，已证实吴茱萸碱可显著抑制多种癌细胞的增殖，并介导细胞周期阻滞和细胞迁移等细胞过程。此外，吴茱萸碱对心血管疾病（高脂血症等）以及手足癣显示出显著的药理活性。最近，发现吴茱萸碱具有潜在的毒性作用，如肝毒性、肾毒性和心脏毒性。然而，吴茱萸碱的药理和毒理机制尚不清楚，其体内外毒性也鲜有报道。因此，本研究综述了近年来吴茱萸碱的药理和毒理文章，旨在为未来研究提供新思路和参考。
