School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Department of Pharmacy, Sichuan Province Orthopedic Hospital, Chengdu 610041, China.
Biomed Pharmacother. 2023 Nov;167:115495. doi: 10.1016/j.biopha.2023.115495. Epub 2023 Sep 21.
Evodia rutaecarpa, the near-ripe fruit of Euodia rutaecarpa (Juss.) Benth, Euodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang, or Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang, is a famous herbal medicine with several biological activities and therapeutic values, which has been applied for abdominalgia, abdominal distension, vomiting, and diarrhea as a complementary and alternative therapy in clinic. Indole alkaloids, particularly evodiamine (EVO), rutaecarpine (RUT), and dedhydroevodiamine (DHE), are received rising attention as the major bioactivity compounds in Evodia rutaecarpa. Therefore, this review summarizes the physicochemical properties, pharmacological activities, pharmacokinetics, and therapeutic effects on gastrointestinal diseases of these three indole alkaloids with original literature collected by PubMed, Web of Science Core Collection, and CNKI up to June 2023. Despite sharing the same parent nucleus, EVO, RUT, and DHE have different structural and chemical properties, which result in different advantages of biological effects. In their wide range of pharmacological activities, the anti-migratory activity of RUT is less effective than that of EVO, and the neuroprotection of DHE is significant. Additionally, although DHE has a higher bioavailability, EVO and RUT display better permeabilities within blood-brain barrier. These three indole alkaloids can alleviate gastrointestinal inflammatory in particular, and EVO also has outstanding anti-cancer effect, although clinical trials are still required to further support their therapeutic potential.
吴茱萸，近成熟果实的吴茱萸（Juss.）Benth，吴茱萸（Juss.）Benth。var. officinalis（Dode）Huang 或吴茱萸（Juss.）Benth。var. bodinieri（Dode）Huang，是一种具有多种生物活性和治疗价值的著名草药，已在临床上用于治疗腹痛、腹胀、呕吐和腹泻等疾病。吲哚生物碱，特别是吴茱萸碱（EVO）、吴茱萸碱（RUT）和去氢吴茱萸碱（DHE），作为吴茱萸中的主要生物活性化合物，受到越来越多的关注。因此，本综述总结了这三种吲哚生物碱的理化性质、药理活性、药代动力学以及对胃肠道疾病的治疗作用，原始文献来源于截至 2023 年 6 月的 PubMed、Web of Science Core Collection 和中国知网。尽管具有相同的母核，但 EVO、RUT 和 DHE 具有不同的结构和化学性质，这导致了它们在生物效应方面的不同优势。在它们广泛的药理活性中，RUT 的抗迁移活性不如 EVO 有效，而 DHE 的神经保护作用显著。此外，尽管 DHE 具有更高的生物利用度，但 EVO 和 RUT 在血脑屏障内显示出更好的通透性。这三种吲哚生物碱可以特别缓解胃肠道炎症，而 EVO 还具有出色的抗癌作用，尽管仍需要临床试验来进一步支持它们的治疗潜力。
