Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Andrologia. 2022 Mar;54(2):e14298. doi: 10.1111/and.14298. Epub 2021 Nov 5.
Infertility is a multiplex disorder in the reproductive system, and men are responsible for more than half of the cases. Nowadays, semen analysis has been considered the critical assessment test to diagnose infertile men; however, it has limitations so that the cause behind infertility in 40% of infertile men is unrevealed. Weaknesses of semen assessment indicate a global need for novel and better diagnostic tools and biomarkers. MicroRNAs are short (about 18-22 nucleotide length) non-coding RNAs that control most (>60%) of our protein-coding genes post-transcriptionally. These molecules are aberrant in the body fluids, and abnormal alterations in their expression level can signify a specific disease such as infertility. Therefore, microRNAs can be novel candidate biomarkers that can diagnose different types of male infertility, including azoospermia, oligozoospermia, asthenozoospermia and teratozoospermia. This narrative review aimed to collect and sum up new papers published about the significant role of microRNAs in different male infertility categories.
不育症是生殖系统的一种多因素疾病，其中男性因素占一半以上。目前，精液分析被认为是诊断男性不育症的关键评估测试；然而，它具有一定的局限性，导致 40%的不育男性的不育原因仍未得到揭示。精液评估的局限性表明，全球需要新型和更好的诊断工具和生物标志物。microRNAs 是短链（约 18-22 个核苷酸长度）的非编码 RNA，可在后转录水平上调控我们大多数（>60%）的蛋白编码基因。这些分子在体液中异常，其表达水平的异常改变可以表明特定疾病，如不育症。因此，microRNAs 可以成为新型候选生物标志物，用于诊断不同类型的男性不育症，包括无精症、少精症、弱精症和畸形精症。本综述旨在收集和总结关于 microRNAs 在不同男性不育症类别中重要作用的新发表论文。
