非编码 RNA 在非梗阻性无精子症中的基因调控作用。
The gene regulatory role of non-coding RNAs in non-obstructive azoospermia.
机构信息
Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 18;13:959487. doi: 10.3389/fendo.2022.959487. eCollection 2022.
Non-coding RNAs are classified as small non-coding RNAs, long non-coding RNAs and circular RNAs, which are involved in a variety of biological processes, including cell differentiation, proliferation, apoptosis and pathological conditions of various diseases. Many studies have shown that non-coding RNAs are related to spermatogenesis, maturation, apoptosis, function, etc. In addition, the expression of non-coding RNAs in testicular tissue and semen of patients with non-obstructive azoospermia was different. However, the role of non-coding RNAs in the pathogenesis of non-obstructive azoospermia has not been fully elucidated, and the role of non-coding RNAs in non-obstructive azoospermia is rarely reviewed. Here we summarize the research progress of non-coding RNAs in the pathogenesis of non-obstructive azoospermia.
非编码 RNA 分为小非编码 RNA、长非编码 RNA 和环状 RNA，它们参与多种生物学过程，包括细胞分化、增殖、凋亡和各种疾病的病理状态。许多研究表明，非编码 RNA 与精子发生、成熟、凋亡、功能等有关。此外，非梗阻性无精子症患者睾丸组织和精液中非编码 RNA 的表达不同。然而，非编码 RNA 在非梗阻性无精子症发病机制中的作用尚未完全阐明，非编码 RNA 在非梗阻性无精子症中的作用很少被综述。本文总结了非编码 RNA 在非梗阻性无精子症发病机制中的研究进展。
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