Dugan J M, Atkinson B F, Avitabile A, Schimmel M, LiVolsi V A
Acta Cytol. 1987 May-Jun;31(3):330-4.
Psammoma bodies are concentric, laminated microcalcifications that are regarded as nearly specific markers in the thyroid gland for the presence of papillary carcinoma. While psammoma bodies have been seen rarely in some benign thyroid diseases, there appear to be no reports of psammoma body formation in lymphocytic or Hashimoto's thyroiditis. We report a case of Hashimoto's thyroiditis in which psammoma bodies were identified in a fine needle aspiration specimen of the thyroid and in histologic sections of the right thyroid lobectomy; papillary carcinoma was not found in either specimen. We conclude that psammoma bodies may be seen in any benign process, such as nodular goiter or lymphocytic thyroiditis, that produces reactive papillary hyperplasia of thyroid epithelium, as well as in papillary carcinoma. However, the finding of psammoma bodies in a fine needle aspirate without corroborating cytologic evidence of papillary cancer is still an indication for surgical removal of the thyroid nodule since these structures are reliable markers for occult papillary carcinoma of the thyroid, despite the rarity of their formation in benign diseases.
砂粒体是同心层状的微小钙化，被视为甲状腺乳头状癌几乎具有特异性的标志物。虽然在一些良性甲状腺疾病中很少见到砂粒体，但似乎尚无淋巴细胞性或桥本甲状腺炎中形成砂粒体的报道。我们报告1例桥本甲状腺炎，在甲状腺细针穿刺标本及右侧甲状腺叶切除术的组织切片中均发现了砂粒体；在任何一个标本中均未发现乳头状癌。我们得出结论，在任何导致甲状腺上皮反应性乳头状增生的良性过程中，如结节性甲状腺肿或淋巴细胞性甲状腺炎，以及在乳头状癌中，均可出现砂粒体。然而，在细针穿刺抽吸物中发现砂粒体而无乳头状癌的确证细胞学证据，仍然是手术切除甲状腺结节的指征，因为这些结构是甲状腺隐匿性乳头状癌的可靠标志物，尽管它们在良性疾病中形成罕见。
