Riazmontazer N, Bedayat G
Department of Pathology, Shiraz University School of Medicine, Iran.
Acta Cytol. 1991 Sep-Oct;35(5):563-6.
Psammoma bodies present in fine needle aspiration (FNA) smears with typical cytologic features of colloid goiter from five patients raised the possibility of coexistent papillary carcinoma. However, subsequent careful histologic examination of the entire thyroidectomy specimens did not show occult carcinoma in any of the cases. The psammoma bodies were identified in the stroma next to the foci of papillary hyperplasia in each case. They were small, often equal in size to or slightly larger than the follicular epithelial cell nuclei, and could be misinterpreted as epithelial cell nuclei. These findings suggest that the presence of psammoma bodies in an FNA smear cytologically consistent with a colloid goiter should raise the possibility of coexistent papillary hyperplasia or neoplasia. However, because of the strong statistical association of psammoma bodies with malignant thyroid neoplasms, histologic confirmation is mandatory in such cases.
在5例具有典型胶样甲状腺肿细胞学特征的细针穿刺（FNA）涂片中出现的砂粒体，提示可能并存乳头状癌。然而，随后对整个甲状腺切除标本进行的仔细组织学检查显示，所有病例均未发现隐匿性癌。在每例病例中，砂粒体均在乳头状增生灶旁的间质中被发现。它们体积小，大小常与滤泡上皮细胞核相等或略大于滤泡上皮细胞核，可能被误诊为上皮细胞核。这些发现表明，在细胞学上与胶样甲状腺肿一致的FNA涂片中出现砂粒体，应提高并存乳头状增生或肿瘤形成的可能性。然而，由于砂粒体与甲状腺恶性肿瘤有很强的统计学关联，在这种情况下必须进行组织学确认。
