从……中分离出的一对新的氧化吲哚生物碱。（注：原文中“from”后缺少具体来源信息）

A pair of new oxindole alkaloids isolated from .

作者信息

Liang Xin-Xin, Yang Jin-Xuan, Li Jian-Mei, Huang Jia-Bi, Yang Liu-Meng, Sun Tian-Tian, Luo Rong-Hua, Xiao Wei-Lie, Zheng Yong-Tang, Li Xiao-Li

机构信息

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, China.

Key Laboratory of Bioactive Peptides of Yunnan Province & Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

出版信息

Nat Prod Res. 2023 Apr;37(8):1258-1264. doi: 10.1080/14786419.2021.2000982. Epub 2021 Nov 5.

DOI:10.1080/14786419.2021.2000982

PMID:34738856

Abstract

A pair of new oxindole alkaloids, named macrophyllines C () and D (), together with two known oxindole alkaloids isorhynchophylline () and corynoxine () were isolated from . Their structures were elucidated based on detailed spectroscopic analysis and by comparison with literature data. In addition, all the isolates were tested for their anti-HIV activities and cytotoxicities in C8166 cells and compounds showed weak anti-HIV activities with EC values of 11.31 ± 3.29 μM, 18.77 ± 6.14 μM and 30.02 ± 3.73 μM, respectively.

摘要

从[具体来源未给出]中分离出一对新的氧化吲哚生物碱，命名为大叶素C（[具体结构未给出]）和大叶素D（[具体结构未给出]），以及两种已知的氧化吲哚生物碱异钩藤碱（[具体结构未给出]）和钩吻素子（[具体结构未给出]）。基于详细的光谱分析并与文献数据比较确定了它们的结构。此外，对所有分离物进行了C8166细胞中的抗HIV活性和细胞毒性测试，化合物[具体化合物未明确]分别表现出较弱的抗HIV活性，其EC值为11.31±3.29μM、18.77±6.14μM和30.02±3.73μM。