钩藤中具有抗线虫活性的四环吲哚生物碱。
Tetracyclic indole alkaloids with antinematode activity from Uncaria rhynchophylla.
作者信息
Kong Fandong, Ma Qingyun, Huang Shengzhuo, Yang Shuang, Fu Linran, Zhou Liman, Dai Haofu, Yu Zhifang, Zhao Youxing
机构信息
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou , China.
b College of Food Science and Technology , Nanjing Agricultural University , Nanjing , China.
出版信息
Nat Prod Res. 2017 Jun;31(12):1403-1408. doi: 10.1080/14786419.2016.1255885. Epub 2016 Nov 11.
A new tetracyclic indole alkaloid, 17-O-methyl-3,4,5,6-tetradehydrogeissoschizine, together with seven known ones, were isolated from the aerial part of Uncaria rhynchophylla. Their structures were unambiguously elucidated by spectroscopic methods and comparing with the literature data. Among them, compounds 1, 3, 4 and 6-8 showed potent to moderate antinematode activities against Panagrellus redivevus at a concentration of 250 μg/mL.
从钩藤的地上部分分离得到一种新的四环吲哚生物碱17 - O - 甲基 - 3,4,5,6 - 四脱氢钩吻素子，以及七种已知生物碱。通过光谱方法并与文献数据比较，明确阐明了它们的结构。其中，化合物1、3、4和6 - 8在浓度为250μg/mL时对小杆线虫显示出强效至中度的抗线虫活性。
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