大头青藤中的新吲哚生物碱大头青藤素和大头青藤碱 A、B。
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
出版信息
J Nat Prod. 2011 Jan 28;74(1):12-5. doi: 10.1021/np1004938. Epub 2010 Nov 11.
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.
从钩藤的地上部分分离得到一个不寻常的吲哚生物碱内盐，macrophyllionium（1），以及一对新的四环吲哚生物碱，macrophyllines A（2）和 B（3），以及六个已知的生物碱。科里那丁（8）对 HL-60 和 SW480 细胞表现出中等的细胞毒性，IC（50）值分别为 13.96 和 23.28 μM。二氢科里那丁（9）对苯肾上腺素诱导的大鼠胸主动脉环收缩具有显著的舒张活性（IC（50）= 6.73 μg/mL）。此外，化合物 2、6 和 9 对 KCl 诱导的收缩表现出较弱的抑制作用。
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