Gelberg K H, Fitzgerald E F, Hwang S, Dubrow R
New York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, NY 12203, USA.
Int J Epidemiol. 1997 Apr;26(2):272-8. doi: 10.1093/ije/26.2.272.
Risk factors for osteosarcoma in young people were investigated in a population-based case-control study among residents of New York State, excluding New York City.
Cases (n = 130) were diagnosed between 1978 and 1988 at < or = 24 years of age. Controls were randomly selected from birth certificates and were pair matched to cases on year of birth and sex. Exposure information was obtained by telephone interview with a subject and/or parent, and from birth certificates and school and medical records.
A significant positive association was observed with height one year before diagnosis (P-value for trend = 0.02). No significant associations were observed between osteosarcoma and weight of body mass index one year before diagnosis, birth length, birthweight, gestational age, having reached puberty, having begun growth spurt, age at puberty, age growth spurt began, medical x-rays, antenatal exposures, family history of cancer, birth defects, or parental occupation.
在一项针对纽约州（不包括纽约市）居民的基于人群的病例对照研究中，对年轻人骨肉瘤的危险因素进行了调查。
病例（n = 130）于1978年至1988年间被诊断出年龄小于或等于24岁。对照是从出生证明中随机选取的，并在出生年份和性别上与病例进行配对。暴露信息通过对受试者和/或其父母的电话访谈以及出生证明、学校和医疗记录获得。
在诊断前一年的身高方面观察到显著的正相关（趋势P值 = 0.02）。在骨肉瘤与诊断前一年的体重、体重指数、出生身长、出生体重、胎龄、进入青春期、开始生长突增、青春期年龄、生长突增开始年龄、医学X光检查、产前暴露、癌症家族史、出生缺陷或父母职业之间未观察到显著关联。
