Giri N, Nair C N, Pai S K, Kurkure P A, Gopal R, Advani S H
Am J Pediatr Hematol Oncol. 1987 Summer;9(2):143-5. doi: 10.1097/00043426-198722000-00006.
Avascular necrosis of bone (AVNB) is a known complication of systemic adrenocorticosteroid therapy and is thought to be dose related. However, despite the large amount of prednisolone that has been used in the standard treatment of acute lymphoblastic leukemia (ALL), AVNB has rarely been reported with this disease. We have described our experience with an adolescent girl with ALL who developed multifocal AVNB after aggressive chemotherapy, which included high cumulative doses of corticosteroids along with other cytotoxic drugs, some of which have been associated with AVNB. Five similar cases from literature are reviewed. The occurrence of AVNB may become more common in the future with the increasing use of aggressive chemotherapy. Awareness of this possibility will lead to a more rapid diagnosis and early treatment of AVNB.
骨缺血性坏死（AVNB）是全身使用肾上腺皮质类固醇激素治疗已知的并发症，且被认为与剂量相关。然而，尽管在急性淋巴细胞白血病（ALL）的标准治疗中使用了大量泼尼松龙，但很少有关于这种疾病并发AVNB的报道。我们描述了一名患有ALL的青春期女孩的经历，她在积极化疗后出现了多灶性AVNB，化疗方案包括高累积剂量的皮质类固醇以及其他细胞毒性药物，其中一些药物已被证实与AVNB有关。我们还回顾了文献中五例类似病例。随着积极化疗的使用增加，AVNB的发生在未来可能会变得更加普遍。认识到这种可能性将有助于更快速地诊断和早期治疗AVNB。
