Geetha N, Kumary P K, Ramachandran K, Nair M K
Regional Cancer Centre, Kerala, India.
Pediatr Hematol Oncol. 1998 Sep-Oct;15(5):443-6. doi: 10.3109/08880019809016574.
Avascular necrosis of bone is a well-described complication of cancer chemotherapy containing corticosteroids, and has been observed in lymphomas and acute lymphoblastic leukemia. Avascular necrosis occurring in association with neuroblastoma has never been reported before. This study reports on a 7-year-old boy with stage IV neuroblastoma developing avascular necrosis of the femoral head of both hips during treatment with combination chemotherapy using cyclophosphamide, cisplatin, etoposide, and doxorubicin. He was given conservative treatment in view of the progressive disease.
骨缺血性坏死是含皮质类固醇的癌症化疗中一种广为人知的并发症，在淋巴瘤和急性淋巴细胞白血病中已有观察到。与神经母细胞瘤相关的骨缺血性坏死此前从未有过报道。本研究报告了一名7岁患有IV期神经母细胞瘤的男孩，在使用环磷酰胺、顺铂、依托泊苷和阿霉素联合化疗期间出现双侧股骨头缺血性坏死。鉴于疾病进展，给予了他保守治疗。
