Department of Ophthalmology, Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital, Ankara, Turkey.
Department of Ophthalmology, Ankara City Hospital, Ankara, Turkey.
Int Ophthalmol. 2022 Apr;42(4):1311-1316. doi: 10.1007/s10792-021-02118-z. Epub 2021 Nov 5.
Pseudoexfoliation syndrome (PES) is an age-related process associated with glaucoma and cataracts. It increases the risk of complications during cataract surgery. Blood neutrophil-to-lymphocyte ratio (NLR) is shown to be an effective biomarker of inflammation in PES. We aimed to investigate association of NLR and pseudoexfoliation (PEX) related cataract surgery complications.
A total of 210 eyes who underwent cataract surgery between January 2016 and January 2020 in our department were analyzed retrospectively. Patients were grouped with respect to developing complications and the two groups were compared. Medical records were reached to obtain neutrophil and lymphocyte values to calculate NLR. Data obtained were analyzed using chi-square test. Receiver operating characteristics curve analysis was performed to determine cutoff, sensitivity and specificity values. p value of ≤ 0.05 was considered statistically significant.
The mean age was 68.1 ± 7.2 years and mean NLR was 2.11 ± 0.81. Complications were observed in 32 (15.2%) of the patients (group 1). Neutrophil counts (5.19 ± 0.64 vs. 4.43 ± 0.86, p < 0.001) and the NLR (2.68 ± 0.73 vs. 2.01 ± 0.81, p < 0.001) of group 1 were significantly higher than group 2. The ROC analysis revealed a cutoff value of 2.33 for NLR to predict cataract surgery complications with sensitivity of 87.5% and specificity of 78.1%.
There is an association between NLR and increased risk of complications during cataract surgery in PES patients. NLR can be used as an easy method to help ophthalmologists in predicting the risks associated with cataract surgery in PEX eyes.
假性剥脱综合征（PES）是一种与青光眼和白内障相关的年龄相关性疾病。它会增加白内障手术期间发生并发症的风险。中性粒细胞与淋巴细胞比值（NLR）已被证明是 PES 炎症的有效生物标志物。我们旨在研究 NLR 与假性剥脱（PEX）相关白内障手术并发症的关系。
回顾性分析了 2016 年 1 月至 2020 年 1 月期间在我科行白内障手术的 210 只眼。根据是否发生并发症将患者分为两组，并对两组进行比较。查阅病历以获取中性粒细胞和淋巴细胞值来计算 NLR。使用卡方检验分析数据。进行受试者工作特征曲线分析以确定截断值、灵敏度和特异性值。p 值≤0.05 被认为具有统计学意义。
患者平均年龄为 68.1±7.2 岁，平均 NLR 为 2.11±0.81。32 例（15.2%）患者出现并发症（组 1）。组 1 的中性粒细胞计数（5.19±0.64 与 4.43±0.86，p<0.001）和 NLR（2.68±0.73 与 2.01±0.81，p<0.001）均显著高于组 2。ROC 分析显示 NLR 的截断值为 2.33 预测白内障手术并发症的灵敏度为 87.5%，特异性为 78.1%。
在 PES 患者中，NLR 与白内障手术期间发生并发症的风险增加有关。NLR 可以作为一种简单的方法，帮助眼科医生预测 PEX 眼中白内障手术相关的风险。
