Ilhan Cagri, Citirik Mehmet, Uzel Mehmet Murat, Tekin Kemal
Department of Ophthalmology, Hatay State Hospital, Hatay, Turkey.
Department of Ophthalmology, University of Health Sciences, Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
Med Hypothesis Discov Innov Ophthalmol. 2019 Spring;8(1):22-27.
This study was conducted to reveal the role of systemic low-grade inflammation by calculating the Neutrophil/Lymphocyte Ratio (NLR) in Vitreomacular Traction Syndrome (VMTS) of different etiologies. A retrospective examination was made of the medical records at a tertiary referral hospital. The study included 31 patients with diabetic VMTS, 27 patients with idiopathic VMTS, and 35 healthy subjects as the control group. The White Blood Cell (WBC) counts and Neutrophil-to-Lymphocyte Ratio (NLR) was compared. There were insignificant differences between the groups in terms of mean age and female/male ratio (P>0.05). The mean ± Standard Deviation (SD) of NLR was calculated as 2.43 ± 0.83 in the diabetic VMTS group, 2.38 0.96 in the idiopathic VMTS group, and 1.83 WBC: White blood cell; VMTS: Vitreomacular traction syndrome; SD: standard deviation; µL: microliter; fL: femtolitre; n: number. 0.52 in the control group (P=0.007). The values of the diabetic and idiopathic VMTS groups were significantly higher than those of the control group (P=0.002 and P=0.032, respectively). However, differences between the diabetic and idiopathic VMTS groups were insignificant (P=0.651). This study found significantly higher NLR in patients with diabetic and idiopathic VMTS than the control group. Elevated NLR could therefore be a potential indicator of VMTS, irrespective of the etiology.
本研究旨在通过计算不同病因的玻璃体黄斑牵引综合征（VMTS）患者的中性粒细胞/淋巴细胞比值（NLR），揭示全身低度炎症的作用。对一家三级转诊医院的病历进行了回顾性检查。该研究纳入了31例糖尿病性VMTS患者、27例特发性VMTS患者以及35名健康受试者作为对照组。比较了白细胞（WBC）计数和中性粒细胞与淋巴细胞比值（NLR）。各组在平均年龄和女性/男性比例方面无显著差异（P>0.05）。糖尿病性VMTS组NLR的平均值±标准差（SD）计算为2.43±0.83，特发性VMTS组为2.38±0.96，对照组为1.83±0.52（P=0.007）。糖尿病性和特发性VMTS组的值显著高于对照组（分别为P=0.002和P=0.032）。然而，糖尿病性和特发性VMTS组之间的差异不显著（P=0.651）。本研究发现，糖尿病性和特发性VMTS患者的NLR显著高于对照组。因此，无论病因如何，NLR升高可能是VMTS的一个潜在指标。
