Rocchi P, Ferreri A M, Simone G, Prodi G
Anticancer Res. 1987 Mar-Apr;7(2):247-50.
On the basis that inhibition of cell proliferation may play a role in the differentiation process, we have studied the effect of the antineoplastic drug epirubicin, an antibiotic of the anthracycline group, on human neuroblastoma cell lines SK-N-MC, SK-N-SH, SJ-N-KP, TS12 and AF8. Epirubicin induced morphological and biochemical differentiation in these cultured cell lines; treatment with it stimulated the outgrowth of neurites and increased acetylcholinesterase activity.
基于细胞增殖的抑制可能在分化过程中起作用这一观点，我们研究了抗肿瘤药物表柔比星（一种蒽环类抗生素）对人神经母细胞瘤细胞系SK-N-MC、SK-N-SH、SJ-N-KP、TS12和AF8的影响。表柔比星在这些培养的细胞系中诱导了形态学和生化分化；用它处理可刺激神经突的生长并增加乙酰胆碱酯酶活性。
