Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102316. doi: 10.1016/j.dsx.2021.102316. Epub 2021 Oct 25.
The relationship between physical activity levels (PAL) and the presence of cardiovascular disease (CVD) risk factors such as anthropometric and biochemical indices and heat shock proteins 27 antibody (anti-HSP-27) concentration, and serum inflammatory markers, was investigated in the MASHAD cohort study.
The overall study population consisted of 9,684 subjects (3,858 men, 5,826 women) with a mean age of 47.73 ± 8.08 to 48.87 ± 9.26 years respectively. They were divided into four categories based on their PAL. Biochemical parameters were determined for all participants. Also, serum anti-HSP-27 levels were measured using an in-house enzyme-linked immune sorbent assay method. Multiple regression analysis was used to explore the association between the anti-HSP antibody titers and physical activity after adjusting for confounding factors. The level of statistical significance was set at p < 0.05.
Several CVD risk factors were associated with the level of PAL including: body mass index, waist hip ratio, systolic and diastolic blood pressure, serum HDL-C and TG (p < 0.001) and also fasting blood glucose (0.004). Also, serum anti-HSP-27 titers were significantly higher in inactive subjects (P > 0.05).
We found that PAL was significantly associated with several established CVD risk factors. Also, the level of anti-HSP-27 was lower in individuals with moderate and high PAL.
本研究旨在探讨体力活动水平（PAL）与心血管疾病（CVD）风险因素（如人体测量学和生化指标以及热休克蛋白 27 抗体（抗-HSP-27）浓度和血清炎症标志物）之间的关系，该研究基于 MASHAD 队列研究。
该研究的总体研究人群包括 9684 名受试者（3858 名男性，5826 名女性），平均年龄分别为 47.73±8.08 岁至 48.87±9.26 岁。他们根据 PAL 分为四组。对所有参与者进行生化参数测定。此外，使用内部酶联免疫吸附测定法测量血清抗-HSP-27 水平。采用多元回归分析方法，在校正混杂因素后，探讨抗 HSP 抗体滴度与体力活动之间的关系。统计显著性水平设定为 p<0.05。
多项 CVD 风险因素与 PAL 水平相关，包括：体重指数、腰臀比、收缩压和舒张压、血清 HDL-C 和 TG（p<0.001），以及空腹血糖（0.004）。此外，不活跃受试者的血清抗-HSP-27 滴度显著升高（P>0.05）。
我们发现 PAL 与多项已确立的 CVD 风险因素显著相关。此外，中等和高强度 PAL 个体的抗-HSP-27 水平较低。
