State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, People's Republic of China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, People's Republic of China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China.
Biomaterials. 2021 Dec;279:121225. doi: 10.1016/j.biomaterials.2021.121225. Epub 2021 Oct 28.
The development of a rapid-forming in-situ sprayable hydrogel with the functions of tumor treatment and wound healing is essential for eliminating residual tumor tissue and promoting wound healing caused by surgical resection. On account of its semiconductor properties, β-FeSi (FS) was widely explored as a thermoelectric material. In this work, FS was first applied as a bioactive material for the application of tissue engineering. Excitedly, we found that FS could be used as a novel antitumor agent. It exhibited excellent photothermal performance, and the released Fe ions could generate •OH under the acidic conditions and excessive HO in the tumor microenvironment. Moreover, the sprayable β-FeSi-incorporated sodium alginate (FS/SA) hydrogel was prepared as an instant gelation after spraying in situ, contributing to timely tumor-induced skin wound healing and efficiently suppressing tumors through photothermal and chemodynamic therapy (PTT and CDT). Furthermore, the released bioactive Fe and Si ions could promote the migration and differentiation of endothelial cells and the pro-angiogenesis of skin wounds. Accordingly, such sprayable hydrogel played an effective role in emergency wound treatment with the advantage of convenience and portability. Overall, with incorporation of FS into the sprayable FS/SA hydrogel, the composite hydrogel possessed dual functions of tumor therapy and skin wound healing.
开发一种具有肿瘤治疗和伤口愈合功能的快速成型原位可喷涂水凝胶对于消除手术切除引起的残留肿瘤组织和促进伤口愈合至关重要。由于其半导体性质，β-FeSi（FS）被广泛探索作为热电材料。在这项工作中，FS 首次被用作组织工程应用的生物活性材料。令人兴奋的是，我们发现 FS 可以用作一种新型的抗肿瘤药物。它表现出优异的光热性能，释放的 Fe 离子在酸性条件下和肿瘤微环境中的过量 HO 下可以产生 •OH。此外，可喷涂的β-FeSi 掺入的海藻酸钠（FS/SA）水凝胶在原位喷涂后立即形成凝胶，有助于及时进行肿瘤诱导的皮肤伤口愈合，并通过光热和化学动力学治疗（PTT 和 CDT）有效地抑制肿瘤。此外，释放的生物活性 Fe 和 Si 离子可以促进内皮细胞的迁移和分化以及皮肤伤口的血管生成。因此，这种可喷涂水凝胶在紧急伤口处理中具有方便和便携的优势，发挥了有效的作用。总体而言，通过将 FS 掺入可喷涂的 FS/SA 水凝胶中，复合水凝胶具有肿瘤治疗和皮肤伤口愈合的双重功能。
