Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China.
Adv Healthc Mater. 2024 Feb;13(4):e2302588. doi: 10.1002/adhm.202302588. Epub 2023 Nov 20.
Wound healing remains a critical challenge in regenerative engineering. Great efforts are devoted to develop functional patches for wound healing. Herein, a novel sprayable black phosphorus (BP)-based multifunctional hydrogel with on-demand removability is presented as a joints' skin wound dressing. The hydrogel is facilely prepared by mixing dopamine-modified oxidized hyaluronic acid, cyanoacetategroup-functionalized dextran containing black phosphorus, and the catalyst histidine. The catechol-containing dopamine can not only enhance tissue adhesiveness, but also endow the hydrogel with antioxidant capacity. In addition, benefiting from the photothermal conversion ability of the BP and thermally reversible performance of the formed C═C double bonds between aldehyde groups and cyanoacetate groups, the resulting hydrogel displays excellent antibacterial performance and on-demand dissolving ability under NIR irradiation. Moreover, by loading vascular endothelial growth factor into the hydrogel, the promoted migration and angiogenesis effects of endothelial cells can also be achieved. Based on these features, it is demonstrated that such sprayable BP hydrogels can effectively facilitate joint wounds healing by accelerating angiogenesis, alleviating inflammation, and improving wound microenvironment. Thus, it is believed that this NIR-responsive removable BP hydrogel dressing will put forward an innovative concept in designing wound dressings.
创伤愈合仍然是再生工程中的一个关键挑战。人们正在努力开发用于创伤愈合的功能性贴片。本文提出了一种新型的可喷涂的基于黑磷（BP）的多功能水凝胶，具有按需去除性，可用作关节皮肤创伤敷料。该水凝胶通过混合多巴胺修饰的氧化透明质酸、含有黑磷的氰乙酸酯基功能化葡聚糖和催化剂组氨酸制备而成。含儿茶酚的多巴胺不仅可以增强组织粘附力，还可以赋予水凝胶抗氧化能力。此外，得益于 BP 的光热转换能力和醛基与氰乙酸酯基之间形成的 C═C 双键的热可逆性能，所得水凝胶在近红外辐射下表现出优异的抗菌性能和按需溶解能力。此外，通过将血管内皮生长因子载入水凝胶中，还可以实现促进内皮细胞的迁移和血管生成作用。基于这些特点，证明这种可喷涂的 BP 水凝胶可以通过加速血管生成、减轻炎症和改善伤口微环境来有效促进关节伤口愈合。因此，相信这种近红外响应性可去除的 BP 水凝胶敷料将为设计创伤敷料提出一个创新概念。
