Paulino Emanuel Tenório, Rodrigues Amanda Karine Barros Ferreira, Machado Maria Luiza Dal Pont, de Oliveira Kelly Rayane Vital, Bernardino Alessando César, Quintans-Júnior Lucindo José, Oliveira Aldeídia Pereira, Ribeiro Êurica Adélia Nogueira
Cardiovascular Pharmacology Laboratory, Pharmaceutical Institute Sciences, Federal University of Alagoas, Brazil.
Cardiovascular Pharmacology Laboratory, Pharmaceutical Institute Sciences, Federal University of Alagoas, Brazil.
Life Sci. 2022 Feb 1;290:120087. doi: 10.1016/j.lfs.2021.120087. Epub 2021 Nov 3.
Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effects. This study was conducted to assess the cardioprotective action of TPN against isoproterenol (ISO)-induced cardiotoxicity. Wistar rats were randomly divided into six groups. Rats were orally administered with TPN (25, 50, and 75 mg/kg, respectively) for 15 days, and ISO was administered (85 mg/kg, subcutaneously) on the 14th and 15th days. At the end of the experiment, the hemodynamic, baroreflex test, ECG, biochemical, histological, and morphometric changes were monitored from control and experimental groups, i.e., on the 15th day. ISO-induced myocardial infarcted rats showed an increase in mortality rates, cardiac marker enzymes, tachycardia, hypertrophy, myocardium necrosis, edema, hemorrhagic areas, infiltration of inflammatory cells like lymphocytes, and increased myocardial infarct size. However, pretreatment with TPN significantly inhibited these effects of ISO. The histopathological findings obtained for the myocardium further confirmed the biochemical results. Thus, the present study provides evidence for the efficacy of TPN against ISO-induced myocardial infarction in rats.
α-松油醇（TPN）是从七叶榄仁树树脂中提取的主要成分之一。巴西土著部落将这种植物用作治疗心血管疾病的药物。科学报告表明，TPN具有血管舒张和降压作用。本研究旨在评估TPN对异丙肾上腺素（ISO）诱导的心脏毒性的心脏保护作用。将Wistar大鼠随机分为六组。大鼠分别口服TPN（25、50和75mg/kg），持续15天，并在第14天和第15天皮下注射ISO（85mg/kg）。实验结束时，在第15天监测对照组和实验组的血流动力学、压力反射测试、心电图、生化、组织学和形态学变化。ISO诱导的心肌梗死大鼠死亡率增加、心脏标志物酶升高、心动过速、心肌肥大、心肌坏死、水肿、出血区域、淋巴细胞等炎症细胞浸润以及心肌梗死面积增加。然而，TPN预处理显著抑制了ISO的这些作用。心肌的组织病理学结果进一步证实了生化结果。因此，本研究为TPN对大鼠ISO诱导的心肌梗死的疗效提供了证据。
