灵长类动物口腔内氟化物控释给药系统的评估。

Evaluation of an intraoral controlled release delivery system for fluoride in primates.

作者信息

Shern R J, Mirth D B, Emilson C G, Adderly D D, Bowen W H

出版信息

Community Dent Oral Epidemiol. 1987 Jun;15(3):113-6. doi: 10.1111/j.1600-0528.1987.tb00495.x.

DOI:10.1111/j.1600-0528.1987.tb00495.x

Abstract

An intraoral delivery system designed to release 0.5 mg of fluoride per day was evaluated in short-term studies in primates. This fluoride-releasing device, bonded to the buccal surface of the maxillary right central incisor of each of six monkeys (Macaca fascicularis), produced marked elevations in saliva and plaque fluoride concentrations without increases in serum fluoride concentrations. No changes were observed in the plaque and gingival scores or the populations of various species of plaque bacteria.

摘要

一种设计为每天释放0.5毫克氟化物的口腔内给药系统在灵长类动物的短期研究中进行了评估。这种氟化物释放装置粘结在六只猕猴（食蟹猴）每只的右上颌中切牙颊面，使唾液和菌斑中的氟化物浓度显著升高，而血清氟化物浓度没有增加。菌斑和牙龈评分以及各种菌斑细菌的数量均未观察到变化。