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用于治疗牙科疾病的缓释给药系统。

Sustained-release delivery systems for treatment of dental diseases.

作者信息

Friedman M, Steinberg D

机构信息

Department of Pharmacy, School of Pharmacy, Hebrew University, Jerusalem, Israel.

出版信息

Pharm Res. 1990 Apr;7(4):313-7. doi: 10.1023/a:1015898717936.

DOI:10.1023/a:1015898717936
PMID:2194197
Abstract

Sustained-release delivery systems allow the effective targeting of drugs for treating dental and periodontal diseases. Since dental diseases are chronic, the therapeutic agents used should persist in the oral cavity for as long as possible. Implanting fluoride, chlorhexidine, and other antiseptic agents embedded into sustained-release polymeric matrices into the oral cavity prevents cariogenic plaque accumulation. Both fibers and slab-like sustained-delivery devices bearing chemotherapeutic agents reduced periopathogenic bacteria levels associated with clinical improvement. This review provides useful background information for researchers seeking to develop controlled-release delivery systems for dental applications.

摘要

缓释给药系统能够有效地将药物靶向输送至治疗牙齿和牙周疾病。由于牙齿疾病是慢性疾病，所使用的治疗药物应尽可能长时间地留存于口腔中。将嵌入缓释聚合物基质中的氟化物、洗必泰及其他抗菌剂植入口腔可防止致龋菌斑的积聚。带有化疗药物的纤维状和板状缓释装置均降低了与临床改善相关的牙周病原菌水平。这篇综述为寻求开发用于牙科应用的控释给药系统的研究人员提供了有用的背景信息。

相似文献

1
Sustained-release delivery systems for treatment of dental diseases.用于治疗牙科疾病的缓释给药系统。
Pharm Res. 1990 Apr;7(4):313-7. doi: 10.1023/a:1015898717936.
2
Controlled drug delivery: a new means of treatment of dental diseases.控释给药：一种治疗牙科疾病的新方法。
Compend Contin Educ Dent (Lawrenceville). 1985 Jan;6(1):27-32, 35-6.
3
The effect of local application of a sustained release delivery system of chlorhexidine on plaque accumulation.洗必泰缓释给药系统局部应用对菌斑积聚的影响。
Clin Prev Dent. 1988 Jan-Feb;10(1):23-7.
4
Sustained-release drug delivery of antimicrobials in controlling of supragingival oral biofilms.抗菌药物的缓释给药在控制龈上口腔生物膜中的应用
Expert Opin Drug Deliv. 2017 Apr;14(4):571-581. doi: 10.1080/17425247.2016.1213239. Epub 2016 Sep 22.
5
The status, future, and problems of oral antiseptics.口腔抗菌剂的现状、未来及问题
Curr Opin Periodontol. 1996;3:78-84.
6
[Characteristics, diagnosis and treatment of the most common bacterial diseases of the oral cavity].[口腔最常见细菌性疾病的特征、诊断与治疗]
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Sustained-release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?牙周病治疗中抗菌药物的缓释递送：幻想还是现实？
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8
Chemotherapy of dental plaque infections.牙菌斑感染的化学疗法。
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9
New sustained release dosage form of chlorhexidine for dental use. II. Use in periodontal therapy.
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[Therapeutic action of vitamin B 12 in dental, periodontal and oral diseases caused by experimental chronic benzene intoxication].[维生素B₁₂对实验性慢性苯中毒所致牙齿、牙周及口腔疾病的治疗作用]
Arch Stomatol (Napoli). 1965 Apr-Jun;6(2):123-39.

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本文引用的文献

1
Antibiotics in the treatment of human periodontal diseases.抗生素在人类牙周疾病治疗中的应用
J Periodontol. 1981 Sep;52(9):545-58. doi: 10.1902/jop.1981.52.9.545.
2
The development and in vitro evaluation of acrylic strips and dialysis tubing for local drug delivery.用于局部给药的丙烯酸酯条和透析管的研制及体外评价
J Periodontol. 1982 Nov;53(11):693-9. doi: 10.1902/jop.1982.53.11.693.
3
Experimental use of a slow release device employing chlorhexidine gluconate in areas of acute periodontal inflammation.在急性牙周炎症区域使用含葡萄糖酸洗必泰的缓释装置的实验性应用。
新型缓释克霉唑清漆与克霉唑含片治疗口腔念珠菌病的疗效比较。
Clin Oral Investig. 2015 Mar;19(2):467-73. doi: 10.1007/s00784-014-1259-5. Epub 2014 May 28.
4
Fluoride and chlorhexidine release from filled resins.填充型树脂的氟化物与洗必泰释放。
J Dent Res. 2010 Sep;89(9):1002-6. doi: 10.1177/0022034510374055. Epub 2010 Jun 25.
5
A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis.一种新型克霉唑涂膜剂，用于局部治疗口腔念珠菌病。
Clin Oral Investig. 2010 Feb;14(1):71-8. doi: 10.1007/s00784-009-0275-3. Epub 2009 Apr 29.
6
Development of a system to adsorb drugs onto calcium phosphate materials.
J Mater Sci Mater Med. 2005 Jul;16(7):641-6. doi: 10.1007/s10856-005-2535-3.
7
Bone as an effect compartment : models for uptake and release of drugs.作为效应室的骨骼：药物摄取与释放模型
Clin Pharmacokinet. 2003;42(10):863-81. doi: 10.2165/00003088-200342100-00001.
8
The unusual routes of administration.非常规给药途径。
Eur J Drug Metab Pharmacokinet. 1996 Apr-Jun;21(2):181-7. doi: 10.1007/BF03190268.
J Clin Periodontol. 1982 Mar;9(2):129-33. doi: 10.1111/j.1600-051x.1982.tb01228.x.
4
Effects of subgingival chlorhexidine irrigation of periodontal inflammation.龈下洗必泰冲洗对牙周炎症的影响。
J Clin Periodontol. 1982 Jan;9(1):66-74. doi: 10.1111/j.1600-051x.1982.tb01223.x.
5
Fluoride uptake by powdered human enamel treated with prolonged acting fluoride pellets in vitro.
Arch Oral Biol. 1981;26(2):131-4. doi: 10.1016/0003-9969(81)90083-2.
6
The use of controlled and sustained release agents in dentistry: a review of applications for the control of dental caries.
Pharmacol Ther Dent. 1980;5(3-4):59-67.
7
Fluoride prolonged release preparations for topical use.局部用氟化物长效释放制剂。
J Dent Res. 1980 Aug;59(8):1392-7. doi: 10.1177/00220345800590080601.
8
Clinical evaluation of an intraoral device for the controlled release of fluoride.一种用于氟化物控释的口腔内装置的临床评估
J Am Dent Assoc. 1982 Nov;105(5):791-7. doi: 10.14219/jada.archive.1982.0481.
9
Enhancement of fluoride concentration in saliva after topical application of fluoride sustained-release dosage form on orthodontic plates.在正畸托槽上局部应用氟化物缓释剂型后唾液中氟浓度的升高。
J Pharm Sci. 1984 Jan;73(1):135-6. doi: 10.1002/jps.2600730139.
10
New method for local drug delivery using resorbable base material in periodontal therapy.牙周治疗中使用可吸收基质材料进行局部药物递送的新方法。
Bull Tokyo Med Dent Univ. 1984 Sep;31(3):145-53.