National University of Science and Technology "MISIS", Leninsky Prospect 4, Moscow 119049, Russia.
National University of Science and Technology "MISIS", Leninsky Prospect 4, Moscow 119049, Russia.
Colloids Surf B Biointerfaces. 2022 Jan;209(Pt 1):112183. doi: 10.1016/j.colsurfb.2021.112183. Epub 2021 Oct 27.
To date, significant progress has been achieved in the development of biomedical superelastic Ti-based alloys with high mechanical properties. In view of the high probability of implant-associated infection, an urgent task is to impart bactericidal properties to the material. Herein, advanced superelastic Ti-18Zr-15Nb alloys were surface-etched in a piranha solution, and then Ag nanoparticles were deposited on their surface using a polyol process. This led to the formation of a porous surface layer with a thickness of approximately 100 nm and pore size of less than 20 nm, filled with metallic Ag nanoparticles with an average size of 14 nm. The surface-modified samples showed superior antibacterial activity against E.coli cells. The enhanced bactericidal efficiency is explained by the combination of a higher rate of Ag ions release and direct contact of E.coli cells with Ag nanoparticles.
迄今为止，在开发具有高机械性能的生物医学超弹性 Ti 基合金方面已经取得了重大进展。鉴于植入物相关感染的高概率，当务之急是赋予材料杀菌性能。在此，采用混酸溶液对先进的超弹性 Ti-18Zr-15Nb 合金进行表面蚀刻，然后使用多元醇工艺在其表面沉积 Ag 纳米粒子。这导致形成了厚度约为 100nm 且孔径小于 20nm 的多孔表面层，其中填充有平均尺寸为 14nm 的金属 Ag 纳米粒子。表面改性的样品对大肠杆菌细胞表现出优异的抗菌活性。杀菌效率的提高归因于 Ag 离子释放率的提高和大肠杆菌细胞与 Ag 纳米粒子的直接接触。
