Department of Chemical Engineering, Biotechnology and Materials , Ariel University , Ariel 40700 , Israel.
ACS Appl Mater Interfaces. 2019 Oct 30;11(43):39534-39544. doi: 10.1021/acsami.9b13849. Epub 2019 Oct 17.
Titanium alloys have advanced mechanical properties jointly with high biocompatibility that make them eminently suitable for biomedical applications such as dental and orthopedic implants. Improvement in their osseointegration with human bone can be achieved by the development of hydroxyapatite (HAp) on a Ti alloy surface using different methods of deposition. However, plasma electrolytic oxidation (PEO) treatment has been found to be one of the most promising techniques, due to the formation of high bonding between the bone and the Ti surface. Along with this high bonding, an antibacterial ability of the surface to prevent bacterial infection is also essential. Silver, which is a widely applicable antibacterial agent, was used in this work. First, a titanium oxide coating containing calcium and phosphorus and Ag nanoparticles was formed by PEO treatment. Then, Ti alloy was subjected to hydrothermal treatment to ensure a crystalline formation of HAp. Morphology and phase composition investigations detected the presence of HAp crystals in the coating along with antibacterial agents of silver nanoparticles. The biocompatibility and bioactivity of the created coating were examined by contact angle (CS) measurement and electrochemical impedance spectroscopy (EIS). It was shown that the coating was extensively grown after exposure of the alloy to simulated body fluid (SBF) solution for 7 days with no effect on the Ag nanoparticles. An antibacterial test using and revealed that the coating containing Ag nanoparticles has more significant antibacterial effectiveness compared to a coating that does not contain silver.
钛合金具有先进的机械性能和高度的生物相容性，非常适合牙科和骨科植入物等生物医学应用。通过在 Ti 合金表面使用不同的沉积方法在其表面上开发羟基磷灰石（HAp），可以改善其与人体骨骼的骨整合。然而，由于骨与 Ti 表面之间形成了高结合，等离子电解氧化（PEO）处理已被发现是最有前途的技术之一。除了这种高结合之外，表面还必须具有抗菌能力以防止细菌感染。在这项工作中使用了银，这是一种广泛应用的抗菌剂。首先，通过 PEO 处理形成了含有钙和磷以及 Ag 纳米粒子的氧化钛涂层。然后，对 Ti 合金进行水热处理以确保 HAp 的结晶形成。形貌和相组成研究检测到涂层中存在 HAp 晶体以及银纳米粒子的抗菌剂。通过接触角（CS）测量和电化学阻抗谱（EIS）检查了所制备涂层的生物相容性和生物活性。结果表明，在将合金暴露于模拟体液（SBF）溶液 7 天后，涂层得到了广泛的生长，而 Ag 纳米粒子没有受到影响。使用 和 进行的抗菌试验表明，含有 Ag 纳米粒子的涂层与不含银的涂层相比具有更显著的抗菌效果。
