生物标志物作为危险因素中种族差异的中介 (BioMedioR)：原理、研究设计和统计考虑。
Biomarkers as MEDiators of racial disparities in risk factors (BioMedioR): Rationale, study design, and statistical considerations.
机构信息
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL.
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL.
出版信息
Ann Epidemiol. 2022 Feb;66:13-19. doi: 10.1016/j.annepidem.2021.10.010. Epub 2021 Nov 3.
PURPOSE
Relative to White adults, Black adults have a substantially higher prevalence of hypertension and diabetes, both key risk factors for stroke, cardiovascular disease, cognitive impairment, and dementia. Blood biomarkers have shown promise in identifying contributors to racial disparities in many chronic diseases.
METHODS
We outline the study design and related statistical considerations for a nested cohort study, the Biomarker Mediators of Racial Disparities in Risk Factors (BioMedioR) study, within the 30,239-person biracial REasons for Geographic And Racial Differences in Stroke (REGARDS) study (2003-present). Selected biomarkers will be assessed for contributions to racial disparities in risk factor development over median 9.4 years of follow-up, with initial focus on hypertension, and diabetes. Here we outline study design decisions and statistical considerations for the sampling of 4,400 BioMedioR participants.
RESULTS
The population for biomarker assessment was selected using a random sample study design balanced across race and sex to provide the optimal opportunity to describe association of biomarkers with the development of hypertension and diabetes. Descriptive characteristics of the BioMedioR sample and analytic plans are provided for this nested cohort study.
CONCLUSIONS
This nested biomarker study will examine pathways with the target to help explain racial differences in hypertension and diabetes incidence.
目的
与白人成年人相比，黑人成年人高血压和糖尿病的患病率要高得多，而高血压和糖尿病都是中风、心血管疾病、认知障碍和痴呆的关键危险因素。血液生物标志物已显示出在确定许多慢性疾病中种族差异的贡献方面具有潜力。
方法
我们概述了嵌套队列研究——生物标志物介导的风险因素种族差异研究（BioMedioR 研究）的研究设计和相关统计考虑因素，该研究纳入了双种族 Reasons for Geographic And Racial Differences in Stroke（REGARDS）研究中的 30239 人（2003 年至今）。将评估选定的生物标志物对风险因素发展中种族差异的贡献，随访中位数为 9.4 年，最初重点关注高血压和糖尿病。在这里，我们概述了生物标志物研究设计决策和统计考虑因素，以平衡种族和性别，对 4400 名 BioMedioR 参与者进行抽样。
结果
使用随机样本研究设计选择用于生物标志物评估的人群，在种族和性别之间平衡，以最佳机会描述生物标志物与高血压和糖尿病发展之间的关联。为这个嵌套队列研究提供了 BioMedioR 样本的描述性特征和分析计划。
结论
这个嵌套的生物标志物研究将研究途径，旨在帮助解释高血压和糖尿病发病率的种族差异。
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