可溶性CD14与糖尿病发病风险：中风地理和种族差异原因（REGARDS）研究
Soluble CD14 and Incident Diabetes Risk: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
作者信息
Cruden Kaileen, Wilkinson Katherine, Mukaz Debora Kamin, Plante Timothy B, Zakai Neil A, Long D Leann, Cushman Mary, Olson Nels C
机构信息
Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.
Department of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.
出版信息
J Endocr Soc. 2024 May 23;8(7):bvae097. doi: 10.1210/jendso/bvae097.
CONTEXT
Soluble CD14 (sCD14) is an inflammation biomarker with higher concentrations in White than Black adults. Higher sCD14 is seen in insulin resistance and diabetes. There are limited data on the relationship between sCD14 and incident diabetes.
OBJECTIVE
To determine the association of sCD14 with incident diabetes risk in a large biracial US cohort and evaluate whether relationships differ by race.
DESIGN
This study included 3401 Black and White participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study without baseline diabetes who completed baseline and follow-up in-home visits. Modified Poisson regression models estimated risk ratios (RR) of incident diabetes per 1-SD increment sCD14, with adjustment for risk factors. A sCD14-by-race interaction evaluated whether associations differed by race.
RESULTS
There were 460 cases of incident diabetes over a mean 9.5 years of follow-up. The association of sCD14 with diabetes differed by race ( for interaction < .09). Stratifying by race, adjusting for age, sex, and region, higher sCD14 was associated with incident diabetes in White (RR: 1.15; 95% CI: 1.01, 1.33) but not Black participants (RR: 0.96; 95% CI: 0.86, 1.08). In models adjusted for clinical and sociodemographic diabetes risk factors, the association was attenuated among White participants (RR: 1.10; 95% CI: 0.95, 1.28) and remained null among Black participants (RR: 0.90; 95% CI: 0.80, 1.01).
CONCLUSION
sCD14 was associated with incident diabetes risk in White but not Black adults, but this association was explained by diabetes risk factors.
背景
可溶性CD14（sCD14）是一种炎症生物标志物，在成年白人中的浓度高于黑人。在胰岛素抵抗和糖尿病患者中，sCD14水平较高。关于sCD14与新发糖尿病之间关系的数据有限。
目的
确定美国一个大型混血队列中sCD14与新发糖尿病风险的关联，并评估这种关系是否因种族而异。
设计
本研究纳入了来自中风地理和种族差异原因（REGARDS）研究的3401名黑人和白人参与者，这些参与者在基线时没有糖尿病，并完成了基线和随访的家访。修正泊松回归模型估计了sCD14每增加1个标准差时新发糖尿病的风险比（RR），并对风险因素进行了调整。sCD14与种族的交互作用评估了关联是否因种族而异。
结果
在平均9.5年的随访期间，有460例新发糖尿病病例。sCD14与糖尿病的关联因种族而异（交互作用P＜0.09）。按种族分层，在调整年龄、性别和地区后，较高的sCD14与白人新发糖尿病相关（RR：1.15；95%CI：1.01，1.33），但与黑人参与者无关（RR：0.96；95%CI：0.86，1.08）。在调整了临床和社会人口统计学糖尿病风险因素的模型中，白人参与者中的关联减弱（RR：1.10；95%CI：0.95，1.28），而黑人参与者中仍然无关联（RR：0.90；95%CI：0.80，1.01）。
结论
sCD14与成年白人而非黑人的新发糖尿病风险相关，但这种关联可由糖尿病风险因素解释。
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