系统综述和动物模型暴食的荟萃分析 - 第 1 部分：定义和食物/饮料摄入量的结果。
A systematic review and meta-analysis of animal models of binge eating - Part 1: Definitions and food/drink intake outcomes.
机构信息
The University of Sydney, Faculty of Science, School of Psychology, Sydney, 2006 NSW, Australia.
The University of Sydney, Faculty of Science, School of Psychology, Sydney, 2006 NSW, Australia; The University of Sydney, Brain and Mind Centre, 94 Mallett Street, Camperdown, Sydney, NSW 2050, Australia.
出版信息
Neurosci Biobehav Rev. 2022 Jan;132:1137-1156. doi: 10.1016/j.neubiorev.2021.10.036. Epub 2021 Nov 4.
Binge eating involves consuming excessive amounts of food within a discrete period of time and is associated with significant impairments in binge-eating disorder and bulimia nervosa. While research on clinical binge eating has provided valuable aetiological insights, animal models allow for closer examination of environmental, biological, and developmental risk factors. Numerous animal models of binge eating exist and differ widely in operational definitions of bingeing, animal characteristics and methodological parameters. The current review aimed to synthesise the available published evidence on these models. A systematic review of binge definitions in 170 articles found most studies displayed good face validity. Meta-analyses on 150 articles confirmed that the amount of food or drink consumed by animals under binge conditions was larger than that of non-binge conditions across many protocols. The meta-regression revealed species, strain, and sex moderated binge effect size, with the largest effect observed in studies with female animals and mice. Risk of bias assessment identified that improved reporting of allocation, baseline characteristics and outcome assessment is required in future studies.
暴食症涉及在一个特定时间段内摄入过量的食物，并且与暴食症和神经性贪食症的显著障碍有关。虽然对临床暴食症的研究提供了有价值的病因学见解，但动物模型允许更仔细地检查环境、生物和发育风险因素。存在许多暴食症的动物模型，在暴食的操作定义、动物特征和方法参数方面差异很大。本综述旨在综合现有关于这些模型的发表证据。对 170 篇文章中的暴食定义进行系统综述发现，大多数研究具有良好的表面效度。对 150 篇文章的荟萃分析证实，在许多方案中，动物在暴食条件下消耗的食物或饮料量大于非暴食条件下消耗的量。元回归显示，物种、品系和性别调节暴食效应大小，在使用雌性动物和老鼠的研究中观察到最大的效应。偏倚风险评估表明，未来的研究需要改进对分配、基线特征和结果评估的报告。
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