加蓬共和国出现 B.1.1.318 SARS-CoV-2 病毒谱系和高比例的关注变异株 alpha B.1.1.7。
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon.
机构信息
Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany.
Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
出版信息
Int J Infect Dis. 2022 Jan;114:151-154. doi: 10.1016/j.ijid.2021.10.057. Epub 2021 Nov 3.
OBJECTIVE
Variants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative to understand the distribution of several VOCs in the population, which could have implications for transmissibility and vaccine efficacy.
METHODS
Between February and May 2021, SARS-CoV-2 genomes were sequenced using the Oxford nanopore MinION method and the respective genome diversity was elucidated. Phylogenetic analysis was performed and genomes were classified using pangolin lineages.
RESULTS
The results highlighted an increase (46%) in the alpha VOC (B.1.1.7) in the Gabonese population over the study period. In addition, an increase (31%) in the B.1.1.318 lineage, which is associated with high transmission and impaired vaccine efficacy (D614G+E484K+Y144del), was detected.
CONCLUSION
With the second wave ongoing, these findings highlight the need for surveillance of the SARS-CoV-2 genome in the Republic of Gabon and should provide useful guidance to policymakers in selecting an appropriate vaccine for this population.
目的
与相对较高传染性相关的关注变体（VOCs）似乎正在加蓬迅速传播。因此，了解人群中几种 VOC 的分布情况至关重要，这可能对传染性和疫苗效力有影响。
方法
在 2021 年 2 月至 5 月期间，使用 Oxford nanopore MinION 方法对 SARS-CoV-2 基因组进行测序，并阐明了各自的基因组多样性。进行了系统发育分析，并使用 pangolin 谱系对基因组进行分类。
结果
研究期间，加蓬人群中 alpha VOC（B.1.1.7）的比例增加了 46%。此外，还检测到与高传播和疫苗效力受损（D614G+E484K+Y144del）相关的 B.1.1.318 谱系增加了 31%。
结论
随着第二波疫情的持续，这些发现强调了有必要对加蓬共和国的 SARS-CoV-2 基因组进行监测，并且应该为决策者选择适合该人群的疫苗提供有用的指导。
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